Evidence map›Paper›PMID 39975316›Full record

ArticlebioRxiv : the preprint server for biology2025

DNA methylation as a contributor to dysregulation of

Naiomi Rambarack, Katherine Fodder, Megha Murthy, Christina Toomey, Rohan de Silva, Peter Heutink, Jack Humphrey, Towfique Raj, Tammaryn Lashley, Conceição Bettencourt

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Naiomi RambarackDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Katherine FodderDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Megha MurthyDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Christina ToomeyDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Rohan de SilvaDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Peter HeutinkGerman Center for Neurodegenerative Diseases, Tübingen, Germany.
Jack HumphreyNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY USA.
Towfique RajNash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY USA.ORCID 0000-0002-9355-5704
Tammaryn LashleyDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
Conceição BettencourtDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.ORCID 0000-0001-9090-7690

Funding

Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0M
Human Biomarkers CoreU54NS123743 · NINDS · STANFORD UNIVERSITY · PI FRATTA, PIETRO, GITLER, AARON D. · 2021 to 2025
$8.2M
NIA NIH HHS P30 AG066514NINDS NIH HHS U54 NS123743
6 · The paper itself

Abstract

Frontotemporal lobar degeneration (FTLD) represents a spectrum of clinically, genetically, and pathologically heterogeneous neurodegenerative disorders. The two major FTLD pathological subgroups are FTLD-TDP and FTLD-tau. While the majority of FTLD cases are sporadic, heterogeneity also exists within the familial cases, typically involving mutations in

Indexed as

disease riskDNA methylationEpigeneticsFrontotemporal dementiaFrontotemporal lobar degenerationNeurodegenerationProgressive supranuclear palsy

Identifiers

PMID39975316
PMCPMC11838521

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.