Evidence map›Paper›PMID 39975303›Full record

ArticlebioRxiv : the preprint server for biology2025

Prabesh Bhattarai, Elanur Yilmaz, Elif Öykü Cakir, Hande Yüceer Korkmaz, Annie J Lee, Yiyi Ma, Hilal Celikkaya, Mehmet Ilyas Cosacak, Verena Haage, Xue Wang and 17 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Prabesh BhattaraiORCID 0000-0003-2991-5514
Elif Öykü Cakir
Hande Yüceer Korkmaz
Annie J Lee
Yiyi Ma
Hilal Celikkaya
Mehmet Ilyas Cosacak
Verena Haage
Xue Wang
Nastasia Nelson
Weilin Lin
Yixin Zhang
Tal Nuriel
Dörthe Jülich
Özkan Iş
Scott A Holley
Philip de Jager
Elizabeth Fisher
Kate Tubbesing
Taylor Bertucci
Sally Temple
Nilüfer Ertekin-Taner
Badri N Vardarajan

Funding

The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LEIGH A JOHNSON · 2022 to 2026
$181.1M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Christiane Reitz · 2020 to 2026
$30.1M
Genetic Association Between Alzheimer's Disease and Cardio-Cerebrovascular Risk FactorsK01AG084849 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Annie J Lee · 2024 to 2026
$377k
NIA NIH HHS K01 AG084849NIA NIH HHS P30 AG066462NIA NIH HHS U19 AG078109
6 · The paper itself

Abstract

Blood-brain barrier (BBB) dysfunction is a key feature of Alzheimer's disease (AD), particularly in individuals carrying the Graphical abstract: Accessibility text: This image illustrates the effects of different APOE isoforms (ApoE-ε3 and ApoE-ε4) on blood-brain barrier (BBB) integrity, focusing on the molecular interactions between astrocytes and endothelial cells. This figure emphasizes the detrimental effects of ApoE-ε4 on BBB integrity via fibronectin accumulation and altered signaling pathways. The Highlights:

Identifiers

PMID39975303
PMCPMC11838230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.