Evidence map›Paper›PMID 39975268›Full record

ArticlebioRxiv : the preprint server for biology2025

A privileged ER compartment for post-translational heteromeric assembly of an ion channel.

Sudharsan Kannan, William Kasberg, Liliana R Ernandez, Anjon Audhya, Gail A Robertson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sudharsan KannanDepartment of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0002-0460-0068
William KasbergDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0003-3553-7505
Liliana R ErnandezDepartment of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0009-0009-9801-1712
Anjon AudhyaDepartment of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-7828-5152
Gail A RobertsonDepartment of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705.ORCID 0000-0003-4694-5790

Funding

Translational Control of Cardiac ExcitabilityR01HL131403 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Gail A Robertson · 2016 to 2026
$6.0M
Molecular mechanisms that regulate vesicle formation and transportR35GM134865 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anjon Audhya · 2020 to 2026
$4.8M
Allosteric Regulation of KCNH ChannelsR01NS081320 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERTSON, GAIL A · 2012 to 2022
$3.4M
Mechanisms Underlying Axonopathy in Hereditary Spastic ParaplegiaR01NS124165 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Anjon Audhya · 2022 to 2026
$1.9M
NHLBI NIH HHS R01 HL131403NIGMS NIH HHS R35 GM134865NINDS NIH HHS R01 NS081320NINDS NIH HHS R01 NS124165
6 · The paper itself

Abstract

Mechanisms underlying heterotypic subunit assembly of ion channels and other oligomeric complexes are poorly understood. In the human heart, heteromeric assembly of two isoforms encoded by the

Indexed as

arrhythmiacondensatecotranslational assemblyendoplasmic reticulumhERGIKrlong QT syndromeoligomerizationphase separationprotein traffickingproteostasis

Identifiers

PMID39975268
PMCPMC11838338

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.