Evidence map›Paper›PMID 39975228›Full record

ArticlebioRxiv : the preprint server for biology2025

KHSRP-mediated Decay of Axonally Localized Prenyl-Cdc42 mRNA Slows Nerve Regeneration.

M D Zdradzinski, Lauren S Vaughn, Samaneh Matoo, Kayleigh Trumbull, Ashley Loomis, Elizabeth Thames, Seung Joon Lee, Nora Perrone-Bizzozero, Qun Lu, Jessica M Larsen and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

M D ZdradzinskiDepartment of Biological Sciences, University of South Carolina, Columbia, SC 20208 USA.
Lauren S VaughnDepartment of Biological Sciences, University of South Carolina, Columbia, SC 20208 USA.
Samaneh MatooDepartment of Biological Sciences, University of South Carolina, Columbia, SC 20208 USA.
Kayleigh TrumbullDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC USA 29634.
Ashley LoomisDepartment of Biological Sciences, University of South Carolina, Columbia, SC 20208 USA.
Elizabeth ThamesDepartment of Biological Sciences, University of South Carolina, Columbia, SC 20208 USA.
Seung Joon LeeDepartment of Biological Sciences, University of South Carolina, Columbia, SC 20208 USA.ORCID 0000-0001-6690-2830
Nora Perrone-BizzozeroDepartment of Neurosciences, University of New Mexico, Albuquerque, NM.
Qun LuDepartment of Biological Sciences, University of South Carolina, Columbia, SC 20208 USA.
Jessica M LarsenDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, SC USA 29634.
J L TwissDepartment of Biological Sciences, University of South Carolina, Columbia, SC 20208 USA.ORCID 0000-0001-7875-6682

Funding

The role of acetate fermentation in Entamoeba histolytica growth and infectionP20GM109094 · NIGMS · CLEMSON UNIVERSITY · PI KOZUBOWSKI, LUKASZ · 2016 to 2020
$10.4M
Destabilization of axonal mRNAs by KHSRP complexes during axon regenerationR01NS089633 · NINDS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI TWISS, JEFFERY L · 2015 to 2025
$4.1M
Homeostatic Reset as a New Therapeutic Paradigm for Slow Progression DiseasesR01GM146257 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LU, QUN · 2021 to 2025
$3.4M
Noninvasive nanoparticle-directed therapy to the peripheral nervous systemR01NS142877 · NINDS · CLEMSON UNIVERSITY · PI Jessica Larsen · 2025 to 2026
$638k
Nanoparticle Distributed Intravenous Enzyme Replacement Therapy (NanoDIVERT)R21NS133477 · NINDS · CLEMSON UNIVERSITY · PI LARSEN, JESSICA MARIE · 2023 to 2023
$405k
NIGMS NIH HHS P20 GM109094NIGMS NIH HHS R01 GM146257NINDS NIH HHS R01 NS089633NINDS NIH HHS R01 NS142877NINDS NIH HHS R21 NS133477
6 · The paper itself

Abstract

The small GTPase CDC42 promotes axon growth through actin filament polymerization and this growth is driven by axonal localization of the mRNA encoding the prenylated CDC42 isoform (

Indexed as

nerve regenerationRho GTPaseRNA binding proteinRNA localizationtranslational control

Identifiers

PMID39975228
PMCPMC11839134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.