Evidence map›Paper›PMID 39975161›Full record

ArticlebioRxiv : the preprint server for biology2025

Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs.

Emilia Vartiainen, Dhara Liyanage, Illinca Mazureac, Rachel A Battaglia, Matthew Tegtmeyer, Jax Xu He, Noora Räsänen, Julia Sealock, Steven McCarroll, Ralda Nehme and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emilia VartiainenNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Dhara LiyanageThe Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Illinca MazureacThe Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Rachel A BattagliaThe Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Matthew TegtmeyerThe Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Jax Xu HeThe Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Noora RäsänenNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Julia SealockThe Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Steven McCarrollThe Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Ralda NehmeThe Stanley Center for Psychiatric Research at the Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0001-7215-3311
Olli PietiläinenNeuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-4387-1861

Funding

Unraveling the Genetic Programs Engaged in ASD Neurons Through Coupled Transcriptomic and Phenotypic ReadoutsR01MH128366 · NIMH · BROAD INSTITUTE, INC. · PI Samouil Farhi, Ralda Nehme · 2022 to 2026
$3.7M
NIMH NIH HHS R01 MH128366
6 · The paper itself

Abstract

Astrocytes participate in neuronal synaptic programs that are enriched for genetic associations in schizophrenia and autism spectrum disorders (ASD). To better understand how these co-regulated cellular programs are induced during early neuronal development, we studied astrocytes and iPSC-derived neurons in co-cultures and mono-cultures at 16 time points spanning 0.5 hours to 8 days. We found that upregulation in astrocytes of genes involved in cholesterol biosynthesis preceded the activation of synaptic gene programs in neurons and upregulation of the astrocytic

Identifiers

PMID39975161
PMCPMC11838310

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.