Evidence map›Paper›PMID 39975149›Full record

ArticlebioRxiv : the preprint server for biology2025

An invariant schema emerges within a neural network during hierarchical learning of visual boundaries.

James R Elder, Jie Zheng, Lydia B Shimelis, Ueli Rutishauser, Milo M Lin

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James R ElderGreen Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jie ZhengDepartment of Biomedical Engineering, University of California at Davis, Davis, CA, USA.
Lydia B ShimelisBiomedical Engineering and Neuroscience, Harvard University, Cambridge, MA, USA.
Ueli RutishauserDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Milo M LinGreen Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Funding

Mapping epistatic interactions in molecular evolution of antibiotic resistanceR01GM125748 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Erdal Toprak · 2018 to 2026
$3.6M
Discovering interpretable mechanisms explaining high dimensional biomolecular dataR35GM150897 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Milo Lin · 2023 to 2026
$1.6M
Molecular Biophysics Training ProgramT32GM131963 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Luke W Rice · 2019 to 2026
$1.5M
Circuit Dynamics of Structuring Episodic Memories in HumansR00NS126233 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Jie Zheng · 2024 to 2026
$631k
NIGMS NIH HHS R01 GM125748NIGMS NIH HHS R35 GM150897NIGMS NIH HHS T32 GM131963NINDS NIH HHS R00 NS126233
6 · The paper itself

Abstract

Neural circuits must balance plasticity and stability to enable continual learning without catastrophic forgetting, a pervasive feature of artificial neural networks trained using end-to-end learning (e.g. backpropagation). Here, we apply an alternative, hierarchical learning algorithm to the cognitive task of boundary detection in video clips. In contrast to backpropagation, hierarchical training converges to a network executing a fixed schema and generates firing statistics consistent with single-neuron recordings from human subjects performing the same task. The hierarchically trained network's schema circuit remains invariant following training on sparse data, with additional data serving to refine the upstream representation.

Identifiers

PMID39975149
PMCPMC11838474

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.