Evidence map›Paper›PMID 39975144›Full record

ArticlebioRxiv : the preprint server for biology2025

HIV-1 Vpr drives epigenetic remodeling to enhance virus transcription and latency reactivation.

Nicholas Saladino, Emily Leavitt, Hoi Tong Wong, Jae-Hoon Ji, Diako Ebrahimi, Daniel J Salamango

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Nicholas SaladinoDepartment of Microbiology, Immunology, and Molecular Genetics, UT Health Science Center, San Antonio, Texas, USA, 78229.
Emily LeavittDepartment of Microbiology, Immunology, and Molecular Genetics, UT Health Science Center, San Antonio, Texas, USA, 78229.
Hoi Tong WongDepartment of Microbiology, Mt. Sinai Icahn School of Medicine, New York, New York, USA, 10029.
Jae-Hoon JiDepartment of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, UT Health Science Center, San Antonio, Texas, USA, 78229.
Diako EbrahimiTexas Biomedical Research Institute, San Antonio, Texas, USA, 78227.ORCID 0000-0002-8577-0420
Daniel J SalamangoDepartment of Microbiology, Immunology, and Molecular Genetics, UT Health Science Center, San Antonio, Texas, USA, 78229.

Funding

The Vif-APOBEC NexusR00AI147811 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI SALAMANGO, DANIEL JAMES · 2021 to 2022
$493k
The Vif-APOBEC NexusK99AI147811 · NIAID · UNIVERSITY OF MINNESOTA · PI SALAMANGO, DANIEL JAMES · 2019 to 2020
$238k
NIAID NIH HHS K99 AI147811NIAID NIH HHS R00 AI147811
6 · The paper itself

Abstract

Despite decades of research, the primary proviral function of the HIV-1 Vpr accessory protein remains enigmatic. Vpr is essential for pathogenesis

Indexed as

DNA damage repairepigeneticsHIV-1latency reactivationviral transcriptionVpr

Identifiers

PMID39975144
PMCPMC11838372

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.