Evidence map›Paper›PMID 39975131›Full record

ArticlebioRxiv : the preprint server for biology2025

Centromeres in the thermotolerant yeast

Daniel J Barrero, Sabrine Hedouin, Yizi Mao, Charles L Asbury, Andrew Stergachis, Eileen O'Toole, Sue Biggins

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Daniel J BarreroHoward Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.
Sabrine HedouinHoward Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.
Yizi MaoDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Charles L AsburyDepartment of Neurobiology and Biophysics, 1959 NE Pacific Street, University of Washington, Seattle, WA 98195, USA.
Andrew StergachisDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Eileen O'TooleDepartment of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, CO, USA 80309 USA.
Sue BigginsHoward Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.ORCID 0000-0002-4499-6319

Funding

Reconstitution and biophysical study of chromosome segregation machineryR35GM134842 · NIGMS · UNIVERSITY OF WASHINGTON · PI Charles L Asbury · 2020 to 2026
$4.7M
Investigating the contribution of non-coding genetic variation to rare disordersDP5OD029630 · OD · UNIVERSITY OF WASHINGTON · PI STERGACHIS, ANDREW BEN · 2020 to 2024
$1.9M
Mechanisms underlying chromosome segregationR35GM149357 · NIGMS · FRED HUTCHINSON CANCER CENTER · PI Susan Biggins · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM134842NIGMS NIH HHS R35 GM149357NIH HHS DP5 OD029630
6 · The paper itself

Abstract

Eukaryotic chromosome segregation requires spindle microtubules to attach to chromosomes through kinetochores. The chromosomal locus that mediates kinetochore assembly is the centromere and is epigenetically specified in most organisms by a centromeric histone H3 variant called CENP-A. An exception to this is budding yeast which have short, sequenced-defined point centromeres. In

Indexed as

centromerekinetochoreK. marxianusmicrotubuleS. cerevisiaespindle

Identifiers

PMID39975131
PMCPMC11838225

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.