Evidence map›Paper›PMID 39975088›Full record

ArticlebioRxiv : the preprint server for biology2025

Spatial transcriptomic analysis of HIV and tuberculosis coinfection in a humanized mouse model reveals unique transcription patterns, immune responses and early morphological alterations.

Sitaramaraju Adduri, Jose Alejandro Bohorquez, Rajesh Mani, Omoyeni Adejare, Diego Rincon, Joshua K Kleam, Mounika Duggineni, Andy Omeje, Torry Tucker, Nagarjun V Konduru and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sitaramaraju AdduriDepartment of Cellular and Molecular Biology, School of Medicine, The University of Texas Health Science Center at Tyler, 11937 US HWY 271, Tyler, TX 75708, USA.
Jose Alejandro BohorquezDepartment of Cellular and Molecular Biology, School of Medicine, The University of Texas Health Science Center at Tyler, 11937 US HWY 271, Tyler, TX 75708, USA.
Rajesh ManiDepartment of Cellular and Molecular Biology, School of Medicine, The University of Texas Health Science Center at Tyler, 11937 US HWY 271, Tyler, TX 75708, USA.
Omoyeni AdejareDepartment of Cellular and Molecular Biology, School of Medicine, The University of Texas Health Science Center at Tyler, 11937 US HWY 271, Tyler, TX 75708, USA.
Diego RinconUnaffiliated pathologist.
Joshua K KleamDepartment of Cellular and Molecular Biology, School of Medicine, The University of Texas Health Science Center at Tyler, 11937 US HWY 271, Tyler, TX 75708, USA.
Mounika DuggineniDepartment of Cellular and Molecular Biology, School of Medicine, The University of Texas Health Science Center at Tyler, 11937 US HWY 271, Tyler, TX 75708, USA.
Andy OmejeDepartment of Cellular and Molecular Biology, School of Medicine, The University of Texas Health Science Center at Tyler, 11937 US HWY 271, Tyler, TX 75708, USA.
Torry TuckerDepartment of Cellular and Molecular Biology, School of Medicine, The University of Texas Health Science Center at Tyler, 11937 US HWY 271, Tyler, TX 75708, USA.
Nagarjun V KonduruDepartment of Cellular and Molecular Biology, School of Medicine, The University of Texas Health Science Center at Tyler, 11937 US HWY 271, Tyler, TX 75708, USA.
Guohua YiDepartment of Cellular and Molecular Biology, School of Medicine, The University of Texas Health Science Center at Tyler, 11937 US HWY 271, Tyler, TX 75708, USA.

Funding

Sirtuin -Dependent Regulation of Tuberculosis and HIV Interactions in MacrophagesR01AI184551 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Janice J Endsley, Chinnaswamy Jagannath · 2024 to 2026
$3.8M
Novel CRISPR-Cas9 protein delivery to T cells in vivo by targeting CD7UG3AI150550 · NIAID · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI YI, GUOHUA · 2019 to 2021
$2.1M
Role of PD-1H mediated monocyte activation in HIV pathogenesisR01HL125016 · NHLBI · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI YI, GUOHUA · 2014 to 2018
$1.5M
NHLBI NIH HHS R01 HL125016NIAID NIH HHS R01 AI184551NIAID NIH HHS UG3 AI150550
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Early granuloma formationHIV and tuberculosis coinfectionHumanized mouse modelImaging mass cytometrySpatial transcriptomics

Identifiers

PMID39975088
PMCPMC11838271

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.