Evidence map›Paper›PMID 39975066›Full record

ArticlebioRxiv : the preprint server for biology2025

Phenotypic and Functional Alterations in Peripheral Blood Mononuclear Cell-Derived Microglia in a Primate Model of Chronic Alcohol Consumption.

Hami Hemati, Madison B Blanton, Heather E True, Jude Koura, Rupak Khadka, Kathleen A Grant, Ilhem Messaoudi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Hami HematiMicrobiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, United States.ORCID 0000-0001-6436-5111
Madison B BlantonPharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, United States.ORCID 0000-0002-1515-1894
Heather E TruePharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, United States.ORCID 0000-0002-6408-1490
Jude KouraMicrobiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, United States.
Rupak KhadkaDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, OR, United States.
Kathleen A GrantDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, OR, United States.ORCID 0000-0002-0380-7219
Ilhem MessaoudiMicrobiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, United States.ORCID 0000-0003-3203-2405

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Stress and Ethanol Self-Administration in MonkeysU01AA013510 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KATHLEEN A GRANT · 2002 to 2026
$11.8M
Monkey Alcohol Tissue Research Resource (MATRR)R24AA019431 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mary Lauren Benton, Verginia Carmella Cuzon Carlson · 2010 to 2026
$10.3M
Impact of chronic ethanol consumption on lung functional and immunological landscape and implication for susceptibility to SARSCoV2 infectionR01AA028735 · NIAAA · UNIVERSITY OF KENTUCKY · PI MESSAOUDI, ILHEM, VARLAMOV, OLEG · 2020 to 2025
$4.4M
NRSA Training CoreTL1TR001997 · NCATS · UNIVERSITY OF KENTUCKY · PI PENDERGAST, JULIE S, STOOPS, WILLIAM WALTON · 2016 to 2025
$4.2M
Uncovering the functional and mechanistic dysregulation of monocytes after abstinence and post-abstinence drinkingF31AA031600 · NIAAA · UNIVERSITY OF KENTUCKY · PI BLANTON, MADISON BROOKE · 2024 to 2025
$70k
NCATS NIH HHS TL1 TR001997NIAAA NIH HHS F31 AA031600NIAAA NIH HHS R01 AA028735NIAAA NIH HHS R24 AA019431NIAAA NIH HHS U01 AA013510NIH HHS P51 OD011092
6 · The paper itself

Abstract

Alcohol-induced dysregulation of microglial activity is associated with neuroinflammation, cognitive decline, heightened risk for neurodegenerative diseases, alcohol dependence, and escalation of alcohol drinking. Given the challenge of longitudinally sampling primary microglia, we optimized an

Indexed as

Chronic Alcohol ConsumptionInduced-microgliaMicrogliaNon-Human PrimateTranscriptome

Identifiers

PMID39975066
PMCPMC11839131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.