Evidence map›Paper›PMID 39975063›Full record

ArticlebioRxiv : the preprint server for biology2025

XDH-1 inactivation causes xanthine stone formation in

Jennifer Snoozy, Sushila Bhattacharya, Brandon Johnson, Robin R Fettig, Ashley Van Asma, Chloe Brede, Sophia G Miller, Martina Ralle, Kurt Warnhoff

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jennifer SnoozyPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Sushila BhattacharyaPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Brandon JohnsonPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Robin R FettigPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Ashley Van AsmaPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Chloe BredePediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Sophia G MillerDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97201, USA.
Martina RalleDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97201, USA.
Kurt WarnhoffPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.ORCID 0000-0002-9503-0557

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Genetic analyses of molybdenum cofactor biologyR35GM146871 · NIGMS · SANFORD RESEARCH/USD · PI Kurt Warnhoff · 2022 to 2026
$2.1M
The Pediatric Biomedical Research ProgramR25HD097633 · NICHD · SANFORD RESEARCH/USD · PI LEE, LANCE, WEIMER, JILL M · 2019 to 2023
$527k
Inductively Coupled Plasma Mass Spectrometer for High Sensitivity Elemental AnalysisS10OD028492 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI RALLE, MARTINA · 2021 to 2021
$336k
NICHD NIH HHS R25 HD097633NIGMS NIH HHS R35 GM146871NIH HHS P40 OD010440NIH HHS S10 OD028492
6 · The paper itself

Abstract

Xanthine dehydrogenase (XDH) is a molybdenum cofactor (Moco) requiring enzyme that catabolizes hypoxanthine into xanthine and xanthine into uric acid, the final steps in purine catabolism. Human patients with mutations in XDH develop xanthinuria which can lead to xanthine stones in the kidney, recurrent urinary tract infections, and renal failure. Currently there are no therapies for treating human XDH deficiency. Thus, understanding mechanisms that maintain purine homeostasis is an important goal of human health. Here, we used the nematode

Identifiers

PMID39975063
PMCPMC11838210

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.