Evidence map›Paper›PMID 39975061›Full record

ArticlebioRxiv : the preprint server for biology2025

Sphingosine-1-phosphate signaling through Müller glia regulates neuroprotection and the accumulation of immune cells in the rodent retina.

Olivia Taylor, Lisa Kelly, Heithem El-Hodiri, Andy J Fischer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Olivia TaylorDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Lisa KellyDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.
Heithem El-HodiriDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-5847-4298
Andy J FischerDepartment of Neuroscience, College of Medicine, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-6123-7405

Funding

Fatty acid binding-proteins and endocannabinoids in the retina; roles in glial reactivity and reprogramming of Muller glia into progenitor cellsR01EY032141 · NEI · OHIO STATE UNIVERSITY · PI FISCHER, ANDY J · 2021 to 2025
$1.9M
NEI NIH HHS R01 EY032141
6 · The paper itself

Abstract

The purpose of this study was to investigate how Sphingosine-1-phosphate (S1P) signaling regulates glial phenotype, neuroprotection, and reprogramming of Müller glia (MG) into neurogenic MG-derived progenitor cells (MGPCs) in the adult mouse retina. We found that S1P-related genes were dynamically regulated following retinal damage.

Identifiers

PMID39975061
PMCPMC11838470

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.