Evidence map›Paper›PMID 39975040›Full record

ArticlebioRxiv : the preprint server for biology2025

Thermodynamic principles link

Julia M Schaepe, Torbjörn Fries, Benjamin R Doughty, Olivia J Crocker, Michaela M Hinks, Emil Marklund, William J Greenleaf

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Julia M SchaepeBioengineering Department, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-0416-0469
Torbjörn FriesScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.
Benjamin R DoughtyGenetics Department, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-0447-4468
Olivia J CrockerGenetics Department, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-9249-6450
Michaela M HinksBioengineering Department, Stanford University, Stanford, CA 94305, USA.ORCID 0009-0005-7918-3544
Emil MarklundScience for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden.ORCID 0000-0002-1150-7304
William J GreenleafGenetics Department, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-1409-3095

Funding

Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2M
High-throughput systematic characterization of regulatory element functionUM1HG009436 · NHGRI · STANFORD UNIVERSITY · PI BASSIK, MICHAEL C, GREENLEAF, WILLIAM JAMES · 2017 to 2021
$5.4M
Genetics and Developmental Biology Training ProgramT32GM141828 · NIGMS · STANFORD UNIVERSITY · PI MARGARET T FULLER, Gavin J Sherlock · 2022 to 2026
$2.6M
NHGRI NIH HHS P50 HG007735NHGRI NIH HHS UM1 HG009436NIGMS NIH HHS T32 GM141828
6 · The paper itself

Abstract

The molecular details governing transcription factor (TF) binding and the formation of accessible chromatin are not yet quantitatively understood - including how sequence context modulates affinity, how TFs search DNA, the kinetics of TF occupancy, and how motif grammars coordinate binding. To resolve these questions for a human TF, erythroid Krüppel-like factor (eKLF/KLF1), we quantitatively compare, in high throughput,

Identifiers

PMID39975040
PMCPMC11838358

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.