Evidence map›Paper›PMID 39975033›Full record

ArticlebioRxiv : the preprint server for biology2025

Solubilization of Membrane Proteins using designed protein WRAPS.

Ljubica Mihaljević, David E Kim, Helen E Eisenach, Pooja D Bandawane, Andrew J Borst, Alexis Courbet, Everton Bettin, Qiushi Liu, Connor Weidle, Sagardip Majumder and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Ljubica MihaljevićDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-3697-7767
David E KimDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-0023-956X
Helen E EisenachDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-3201-4517
Pooja D BandawaneDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-7729-5244
Andrew J BorstDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-4297-7824
Alexis CourbetDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-0539-7011
Everton BettinDepartment of Pediatrics, UConn Health, Farmington, CT 06030-3715, USA.ORCID 0000-0001-5095-2198
Qiushi LiuKymab, a Sanofi Company, Babraham Research Campus, Cambridge, UK.
Connor WeidleDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Sagardip MajumderDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-4736-6945
Xinting LiDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Mila LambDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Analisa Nicole Azcárraga MurrayDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Rashmi RavichandranDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-2630-7487
Elizabeth C WilliamsDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Shuyuan HuDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Lynda StuartDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
Linda GrillováParasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK.
Nicholas R ThomsonParasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK.
Pengxiang ChangKymab, a Sanofi Company, Babraham Research Campus, Cambridge, UK.
Melissa J CaimanoDepartment of Pediatrics, UConn Health, Farmington, CT 06030-3715, USA.
Kelly L HawleyDepartment of Pediatrics, UConn Health, Farmington, CT 06030-3715, USA.ORCID 0000-0001-8587-1662
Neil P KingDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.
David BakerDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA 98195, USA.

Funding

Prevalence of syphilis and other sexually transmitted infections in men and transgender women who have sex with men in Cali, ColombiaU19AI144177 · NIAID · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI SALAZAR, JUAN C · 2019 to 2023
$11.2M
NIAID NIH HHS U19 AI144177
6 · The paper itself

Abstract

The development of therapies and vaccines targeting integral membrane proteins has been complicated by their extensive hydrophobic surfaces, which can make production and structural characterization difficult. Here we describe a general deep learning-based design approach for solubilizing native membrane proteins while preserving their sequence, fold, and function using genetically encoded

Identifiers

PMID39975033
PMCPMC11838538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.