Evidence map›Paper›PMID 39975018›Full record

ArticlebioRxiv : the preprint server for biology2025

BESTDR: Bayesian quantification of mechanism-specific drug response in cell culture.

Thomas O McDonald, Simone Bruno, James P Roney, Ioannis K Zervantonakis, Franziska Michor

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Thomas O McDonaldDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
Simone BrunoDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
James P RoneyProgram in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ioannis K ZervantonakisDepartment of Bioengineering, UPMC Hillman Cancer Center, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-2386-9553
Franziska MichorDepartment of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.

Funding

Macrophage-Fibroblast Communication in Cell Migration and Extracellular Matrix RemodelingR35GM150815 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ioannis Zervantonakis · 2023 to 2026
$1.6M
DMS/NIGMS 1: Statistical modeling and estimation of cellular population dynamicsR01GM144962 · NIGMS · DANA-FARBER CANCER INST · PI MCDONALD, THOMAS · 2021 to 2023
$600k
NIGMS NIH HHS R01 GM144962NIGMS NIH HHS R35 GM150815
6 · The paper itself

Abstract

Understanding drug responses at the cellular level is essential for elucidating mechanisms of action and advancing preclinical drug development. Traditional dose-response models rely on simplified metrics, limiting their ability to quantify parameters like cell division, death, and transition rates between cell states. To address these limitations, we developed

Identifiers

PMID39975018
PMCPMC11839102

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.