ArticlebioRxiv : the preprint server for biology2025
Complex exchanges among plasmids and clonal expansion of lineages shape the population structure and virulence of
Rachel A Laing, Michael J Foster, M Amine Hassani, Benjamin Kotzen, Weihua Huang, Terrence Shea, Stephen F Schaffner, Tjasa Cerar, Lisa Freimark, Eva Ruzic-Sabljic and 11 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
21 authors.
M Amine HassaniMassachusetts General Hospital, Harvard Medical School.
Weihua HuangNew York Medical College.
Terrence SheaBroad Institute of MIT and Harvard.
Stephen F SchaffnerBroad Institute of MIT and Harvard.
Tjasa CerarUniversity of Ljubljana.
Lisa FreimarkBroad Institute of MIT and Harvard.
Eva Ruzic-SabljicUniversity of Ljubljana.
Dionysios LiverisNew York Medical College.
Kurt D ReedUniversity of Wisconsin.
John A BrandaMassachusetts General Hospital, Harvard Medical School.
Allen C SteereMassachusetts General Hospital, Harvard Medical School.
Gary P WormserNew York Medical College.
Franc StrleUniversity Medical Center Ljubljana.
Pardis C SabetiBroad Institute of MIT and Harvard.
Ashlee EarlBroad Institute of MIT and Harvard.
Ira SchwartzNew York Medical College.
Klemen StrleTufts University.
Jacob E LemieuxMassachusetts General Hospital, Harvard Medical School.
Funding
Viral Genomics: evolution, spread, and host interactionsU19AI110818 · NIAID · BROAD INSTITUTE, INC. · PI NEAFSEY, DANIEL E · 2014 to 2024
$66.5MWest African Emerging Infectious Disease Research Center (WA-EIDRC)U01AI151812 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ANDERSEN, KRISTIAN GRAUGAARD, GARRY, ROBERT F · 2020 to 2024
$13.2MDETERMINANTS OF B BURGDORFERI HEMATOGENOUS DISSEMINATIONR01AI045801 · NIAID · NEW YORK MEDICAL COLLEGE · PI SCHWARTZ, IRA S. · 1999 to 2015
$4.9MNUCLEIC ACID-BASED DIANOSTIC PROBES FOR LYME DISEASER01AR041511 · NIAMS · NEW YORK MEDICAL COLLEGE · PI SCHWARTZ, IRA S. · 1991 to 2009
$4.1MMicrobial Determinants of Clinical Heterogeneity in Lyme DiseaseR00AI148604 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LEMIEUX, JACOB ERIC · 2022 to 2023
$500kDefining Host Genetic Factors in Adverse Clinical Outcomes in Lyme DiseaseR21AI144916 · NIAID · WADSWORTH CENTER · PI LIN, YI-PIN, STRLE, KLEMEN · 2019 to 2020
$449kDefining Microbial and Host Factors in Innate Immune Responses in Lyme ArthritisK01AR062098 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI STRLE, KLEMEN · 2012 to 2014
$398kMicrobial Determinants of Clinical Heterogeneity in Lyme DiseaseK99AI148604 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LEMIEUX, JACOB ERIC · 2020 to 2021
$273kNIAID NIH HHS K99 AI148604NIAID NIH HHS R00 AI148604NIAID NIH HHS R01 AI045801NIAID NIH HHS R21 AI144916NIAID NIH HHS U01 AI151812NIAID NIH HHS U19 AI110818NIAMS NIH HHS K01 AR062098NIAMS NIH HHS R01 AR041511
6 · The paper itselfAbstract
Background: In the United States, Results: We used long-read sequencing to generate near-complete assemblies of 62 isolates of human-derived Conclusions: Long-read assemblies reveal that
Indexed as
Borrelia burgdorferigenomicslipoproteinsLyme diseasePathogenicityrecombinationVirulenceWhole Genome Sequencing
Identifiers
PMID39974970
PMCPMC11838331
What OpenQuestion holds
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