Evidence map›Paper›PMID 39974968›Full record

ArticlebioRxiv : the preprint server for biology2025

Early cell cycle genes in cortical organoid progenitors predict interindividual variability in infant brain growth trajectories.

Madison R Glass, Nana Matoba, Alvaro A Beltran, Niyanta K Patel, Tala M Farah, Karthik Eswar, Shivam Bhargava, Karen Huang, Ian Curtin, Sara Ahmed and 29 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Madison R GlassDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Nana MatobaDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Alvaro A BeltranDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Niyanta K PatelDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Tala M FarahDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Karthik EswarDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Shivam BhargavaDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Karen HuangDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Ian CurtinDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Sara AhmedDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Mary SrivastavaDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Emma DrakeDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Liam T DavisDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Meghana YeturiDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Kexin SunDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Michael I LoveDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Jeremy M SimonDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Tanya St JohnDepartment of Speech and Hearing Sciences, University of Washington; Seattle, WA, USA.
Natasha MarrusDepartment of Psychiatry, Washington University School of Medicine; St. Louis, MO, USA.
Juhi PandeyDepartment of Psychiatry, University of Pennsylvania; Philadelphia, PA, USA.
Annette EstesDepartment of Speech and Hearing Sciences, University of Washington; Seattle, WA, USA.
Stephen DagerDepartment of Radiology, University of Washington; Seattle, WA, USA.
Robert T SchultzDepartment of Psychiatry, University of Pennsylvania; Philadelphia, PA, USA.
Kelly BotteronDepartment of Psychiatry, Washington University School of Medicine; St. Louis, MO, USA.
Alan EvansDepartment of Neurology and Neurosurgery, McGill University; Montreal, QC, CA.
Sun Hyung KimCarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Martin StynerCarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Robert C McKinstryDepartment of Psychiatry, Washington University School of Medicine; St. Louis, MO, USA.
D Louis CollinsDepartment of Neurology and Neurosurgery, McGill University; Montreal, QC, CA.
Heather VolkSchool of Public Health, Johns Hopkins; Baltimore, MD, USA.
Kelly BenkeSchool of Public Health, Johns Hopkins; Baltimore, MD, USA.
Lonnie ZwaigenbaumDepartment of Developmental Pediatrics, University of Alberta; Edmonton, AB, CA.
Heather HazlettCarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Adriana S BeltranDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Jessica B GiraultCarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Mark D ShenUNC Neuroscience Center, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Joseph PivenCarolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Jason L SteinDepartment of Genetics, University of North Carolina at Chapel Hill; Chapel Hill, NC, USA.
Infant Brain Imaging Study Network

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Cellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
UNC Neuroscience Center Research Cores: MicroscopyP30NS045892 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ZYLKA, MARK J. · 2003 to 2022
$11.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
IBIS-iPSC: Organoid modeling of cortical surface area hyperexpansion in autism spectrum disorderR01MH130441 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jason Louis Stein · 2023 to 2026
$3.1M
The influence of common genetic variation on brain overgrowth pathwaysR01MH120125 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STEIN, JASON LOUIS · 2019 to 2023
$2.5M
pathQTL: Integrative Multi-Omics Causal Inference of Molecular Mechanisms Leading to Neuropsychiatric IllnessR01MH118349 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LOVE, MICHAEL ISAIAH, STEIN, JASON LOUIS · 2019 to 2023
$2.4M
Quantifying the developmental trajectory of autism-associated brain overgrowth using 3D cellular resolution imagingR01MH121433 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STEIN, JASON LOUIS · 2019 to 2023
$2.2M
Genetic Liability for Autism and Infant Brain and Behavioral DevelopmentK01MH122779 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GIRAULT, JESSICA BULLINS · 2020 to 2024
$919k
Relating interindividual differences in cerebral organoid models to longitudinal infant brain growth and cognitive developmentF31MH124427 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GLASS, MADISON ROSE · 2021 to 2023
$99k
NCI NIH HHS P30 CA016086NICHD NIH HHS P50 HD103573NICHD NIH HHS R01 HD055741NIEHS NIH HHS P30 ES010126NIMH NIH HHS F31 MH124427NIMH NIH HHS K01 MH122779NIMH NIH HHS R01 MH118349NIMH NIH HHS R01 MH120125NIMH NIH HHS R01 MH121433NIMH NIH HHS R01 MH130441NINDS NIH HHS P30 NS045892
6 · The paper itself

Abstract

Human induced pluripotent stem cell (iPSC) derived cortical organoids (hCOs) model neurogenesis on an individual's genetic background. The degree to which hCO phenotypes recapitulate the brain growth of the participants from which they were derived is not well established. We generated up to 3 iPSC clones from each of 18 participants in the Infant Brain Imaging Study, who have undergone longitudinal brain imaging during infancy. We identified consistent hCO morphology and cortical cell types across clones from the same participant. hCO cross-sectional area and production of cortical hem cells were associated with

Indexed as

Cell cyclecortical heminfant brain growthneurogenesisorganoidWNT

Identifiers

PMID39974968
PMCPMC11839139

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.