Evidence map›Paper›PMID 39974965›Full record

ArticlebioRxiv : the preprint server for biology2025

Delayed lubricin injection improves cartilage repair tissue quality in an in vivo rabbit osteochondral defect model.

Donghwan Yoon, Karan Vishwanath, John Dankert, James J Butler, Mohammad T Azam, Arianna L Gianakos, Marshall J Colville, Serafina G Lopez, Matthew J Paszek, Heidi L Reesink and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Donghwan YoonSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY.ORCID 0000-0001-8389-2697
Karan VishwanathDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY.ORCID 0000-0003-2910-9176
John DankertFoot and Ankle Division, Department of Orthopaedic Surgery, New York University Langone Health, New York, NY.
James J ButlerFoot and Ankle Division, Department of Orthopaedic Surgery, New York University Langone Health, New York, NY.
Mohammad T AzamFoot and Ankle Division, Department of Orthopaedic Surgery, New York University Langone Health, New York, NY.
Arianna L GianakosFoot and Ankle Division, Department of Orthopaedic Surgery, New York University Langone Health, New York, NY.
Marshall J ColvilleCollege of Veterinary Medicine, Department of Clinical Sciences, Cornell University, Ithaca, NY.
Serafina G LopezMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY.
Matthew J PaszekSmith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY.
Heidi L ReesinkCollege of Veterinary Medicine, Department of Clinical Sciences, Cornell University, Ithaca, NY.
John G KennedyFoot and Ankle Division, Department of Orthopaedic Surgery, New York University Langone Health, New York, NY.
Lawrence J BonassarSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY.
Rebecca M IrwinMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY.ORCID 0000-0001-6549-9912

Funding

Combined Engineering and Orthopaedics Training ProgramT32AR078751 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI MAHER, SUZANNE A., VAN DER MEULEN, MARJOLEIN C · 2021 to 2025
$1.7M
NIAMS NIH HHS T32 AR078751
6 · The paper itself

Abstract

Osteochondral lesions (OCL) are common among young patients and often require surgical interventions since cartilage has a poor capacity for self-repair. Bone marrow stimulation (BMS) has been used clinically for decades to treat OCLs, however a persisting challenge with BMS and other cartilage repair strategies is the inferior quality of the resulting fibrocartilaginous repair tissue. Lubrication-based therapies have the potential to improve the quality of cartilage repair tissue as joint lubrication is linked to local cartilage tissue strains and subsequent cellular responses including death and apoptosis. Recently, a full length recombinant human lubricin (rhLubricin) was developed and has been shown to lower friction in cartilage. This study investigated the effect of a single delayed injection of rhLubricin on cartilage repair in an

Indexed as

frictionhistologyLubricationtribosupplementtribosupplementation

Identifiers

PMID39974965
PMCPMC11839081

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.