Evidence map›Paper›PMID 39974963›Full record

ArticlebioRxiv : the preprint server for biology2025

Transcriptional control of T cell tissue adaptation and effector function in infants and adults.

Peter A Szabo, Hanna M Levitin, Thomas J Connors, David Chen, Jenny Jin, Puspa Thapa, Rebecca Guyer, Daniel P Caron, Joshua I Gray, Rei Matsumoto and 5 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Peter A SzaboDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032.
Hanna M LevitinDepartment of Systems Biology, Columbia University Medical Center, New York, NY 10032.
Thomas J ConnorsDepartment of Pediatrics, Columbia University Medical Center, New York, NY 10032.
David ChenDepartment of Systems Biology, Columbia University Medical Center, New York, NY 10032.
Jenny JinMedical Scientist Training Program, Columbia University Medical Center, New York, NY 10032.
Puspa ThapaDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032.
Rebecca GuyerDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032.
Daniel P CaronDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032.
Joshua I GrayDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032.
Rei MatsumotoDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032.
Masaru KubotaDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032.
Maigan BruskoDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611.
Todd M BruskoDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32611.
Donna L FarberDepartment of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032.
Peter A SimsDepartment of Systems Biology, Columbia University Medical Center, New York, NY 10032.

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Transcriptomics and Repertoire ProfilingP01AI106697 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2013 to 2026
$31.3M
Viral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber, Peter Alan Sims · 2017 to 2026
$26.4M
Medical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3M
Evolution of T cell immunity in blood and tissues over childhoodU01AI168634 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber · 2022 to 2026
$4.1M
Development of lung T cell responses in infant respiratory immunityU01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2017 to 2021
$3.9M
Columbia University Graduate Training Program in Microbiology and ImmunologyT32AI106711 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas Arpaia, Uttiya Basu · 2014 to 2026
$2.1M
Development of Localized T Cell Immunity in Pediatric Respiratory Tract InfectionK23AI141686 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CONNORS, THOMAS · 2019 to 2023
$973k
Five-laser Aurora spectral flow cytometerS10OD030282 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CREUSOT, REMI J · 2022 to 2022
$361k
NCI NIH HHS P30 CA013696NIAID NIH HHS K23 AI141686NIAID NIH HHS P01 AI106697NIAID NIH HHS T32 AI106711NIAID NIH HHS U01 AI100119NIAID NIH HHS U01 AI168634NIAID NIH HHS U19 AI128949NIGMS NIH HHS T32 GM145440NIH HHS S10 OD030282
6 · The paper itself

Abstract

The first years of life are essential for the development of memory T cells, which rapidly populate the body's diverse tissue sites during infancy. However, the degree to which tissue memory T cell responses in early life reflect those during adulthood is unclear. Here, we use single cell RNA-sequencing of resting and

Identifiers

PMID39974963
PMCPMC11838503

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.