Evidence map›Paper›PMID 39974957›Full record

ArticlebioRxiv : the preprint server for biology2025

Fsr quorum sensing system restricts biofilm growth and activates inflammation in enterococcal infective endocarditis.

Haris Antypas, Verena Schmidtchen, Willy Isao Staiger, Yanhong Li, Rachel Jing Wen Tan, Kenneth Kok Fei Ng, Cheryl Jia Yi Neo, Shalome Meera Radhesh, Frederick Reinhart Tanoto, Ronni Anderson Gonçalves DA Silva and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Haris AntypasSingapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore.ORCID 0000-0003-3643-7899
Verena SchmidtchenDivision of Infectious Diseases, University Hospital Zurich, CH-8091 Zurich, Switzerland.ORCID 0009-0009-2740-9950
Willy Isao StaigerDivision of Infectious Diseases, University Hospital Zurich, CH-8091 Zurich, Switzerland.ORCID 0009-0007-9869-9292
Yanhong LiDepartment of Medicine, University of Pittsburgh, PA, USA.
Rachel Jing Wen TanSingapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore.
Kenneth Kok Fei NgSingapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore.
Cheryl Jia Yi NeoSingapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore.ORCID 0000-0001-8894-0440
Shalome Meera RadheshSingapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore.
Frederick Reinhart TanotoSingapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore.ORCID 0000-0001-9289-4811
Ronni Anderson Gonçalves DA SilvaSingapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore.ORCID 0000-0002-8879-6407
Cristina Colomer WinterDepartment of Microbiology and Molecular Medicine, University of Geneva, Switzerland.ORCID 0000-0003-0103-4977
Caroline ManzanoDepartment of Microbiology and Molecular Medicine, University of Geneva, Switzerland.
Jun Jie WongSingapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore.ORCID 0000-0002-9455-1051
Kevin PetheSingapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore.ORCID 0000-0003-0916-8873
Barbara HasseDivision of Infectious Diseases, University Hospital Zurich, CH-8091 Zurich, Switzerland.
Silvio Daniel BruggerDivision of Infectious Diseases, University Hospital Zurich, CH-8091 Zurich, Switzerland.ORCID 0000-0001-9492-9088
Siu Ling WongLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.ORCID 0000-0002-2294-3187
Daria VAN TyneDepartment of Medicine, University of Pittsburgh, PA, USA.ORCID 0000-0001-7284-0103
Annelies S ZinkernagelDivision of Infectious Diseases, University Hospital Zurich, CH-8091 Zurich, Switzerland.ORCID 0000-0003-4700-1118
Kimberly A KlineSingapore Centre for Environmental Life Sciences Engineering, School of Biological Sciences, Nanyang Technological University, Singapore.ORCID 0000-0002-5472-3074

Funding

Deciphering the genetic basis of differential antibiotic efficacy in Enterococcus faecalis endocarditisR21AI164018 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2022 to 2023
$436k
NIAID NIH HHS R21 AI164018
6 · The paper itself

Abstract

Infective endocarditis (IE) is a life-threatening biofilm-associated infection, yet the factors driving biofilm formation remain poorly understood. Here, we identified the Fsr quorum sensing (QS) system of

Indexed as

biofilmEnterococcus faecalisFsrgelatinaseIL-1βimmune evasioninfective endocarditisquorum sensing

Identifiers

PMID39974957
PMCPMC11839028

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.