Evidence map›Paper›PMID 39974949›Full record

ArticlebioRxiv : the preprint server for biology2025

Mechanism of forced-copy-choice RNA recombination by enteroviral RNA-dependent RNA polymerases.

Jamie J Arnold, Alexandre Martinez, Abha Jain, Xinran Liu, Ibrahim M Moustafa, Craig E Cameron

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jamie J ArnoldDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-2345-9776
Alexandre MartinezDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Abha JainDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599.
Xinran LiuDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Ibrahim M MoustafaDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Craig E CameronDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.ORCID 0000-0002-7564-5642

Funding

RNA DEPENDENT RNA POLYMERASE MECHANISMR01AI045818 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARNOLD, JAMIE JON, CAMERON, CRAIG E. · 1999 to 2025
$7.5M
NIAID NIH HHS R01 AI045818
6 · The paper itself

Abstract

Forced-copy-choice recombination occurs at the end of a template, differing from copy-choice recombination, which happens at internal positions. This mechanism may produce full-length genomes from fragments created by host antiviral responses. Previous studies from our laboratory demonstrated that poliovirus (PV) RNA-dependent RNA polymerase (RdRp) switches to an "acceptor" template

Indexed as

forced-copy-choice recombinationRNA-dependent RNA polymeraseRNA recombinationRNA repairRNA virustemplate switchingviral evolution

Identifiers

PMID39974949
PMCPMC11839138

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.