Evidence map›Paper›PMID 39974907›Full record

ArticlebioRxiv : the preprint server for biology2025

Avid lysosomal acidification in fibroblasts of the Mediterranean mouse

Melissa Sui, Joanne Teh, Kayleigh Fort, Daniel Shaw, Peter Sudmant, Tsuyoshi Koide, Jeffrey M Good, Juan M Vazquez, Rachel B Brem

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Melissa SuiDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-3422-2723
Joanne TehDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Kayleigh FortDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Daniel ShawDivision of Biological Sciences, University of Montana, Missoula, MT 59812, USA.ORCID 0000-0001-8838-304X
Peter SudmantDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-9573-8248
Tsuyoshi KoideNational Institute of Genetics, Mishima, Shizuoka 411-8540, Japan.ORCID 0000-0002-1055-9073
Jeffrey M GoodDivision of Biological Sciences, University of Montana, Missoula, MT 59812, USA.
Juan M VazquezDepartment of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-8341-2390
Rachel B BremDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Funding

Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
Mapping deep evolutionary divergences in cellular models of stress responseR01GM120430 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BREM, RACHEL BETH · 2017 to 2025
$3.9M
Genetic dissection of trait variation between long-diverged mouse speciesR01NS116992 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BAUTISTA, DIANA MICHELE, BREM, RACHEL BETH · 2019 to 2023
$3.8M
Patterns and Mechanisms Underlying Somatic Mutations Across Long-Lived BatsK99AG088361 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI VAZQUEZ, JUAN MANUEL · 2024 to 2024
$139k
NIA NIH HHS K99 AG088361NIA NIH HHS T32 AG000266NIGMS NIH HHS R01 GM120430NINDS NIH HHS R01 NS116992
6 · The paper itself

Abstract

Failures of the lysosome-autophagy system are a hallmark of aging and many disease states. As a consequence, interventions that enhance lysosome function are of keen interest in the context of drug development. Throughout the biomedical literature, evolutionary biologists have discovered that challenges faced by humans in clinical settings have been resolved by non-model organisms adapting to wild environments. Here, we used a primary cell culture approach to survey lysosomal characteristics in selected species of the genus

Identifiers

PMID39974907
PMCPMC11839142

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.