Evidence map›Paper›PMID 39974900›Full record

ArticlebioRxiv : the preprint server for biology2025

Optogenetic restoration of neuron subtype-specific cortical activity ameliorates motor deficits in Huntington's Disease mice.

Sonja Blumenstock, David Arakelyan, Nicholas Del Grosso, Sonja Schneider, Yufeng Shao, Enida Gjoni, Rüdiger Klein, Irina Dudanova, Takaki Komiyama

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sonja BlumenstockDepartment of Neurobiology, Center for Neural Circuits and Behavior, and Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
David ArakelyanDepartment of Neurobiology, Center for Neural Circuits and Behavior, and Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Nicholas Del GrossoDepartment of Molecules - Signaling - Development, Max Planck Institute for Biological Intelligence, 82152 Martinsried, Germany.
Sonja SchneiderDepartment of Molecules - Signaling - Development, Max Planck Institute for Biological Intelligence, 82152 Martinsried, Germany.
Yufeng ShaoDepartment of Neurobiology, Center for Neural Circuits and Behavior, and Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Enida GjoniDepartment of Neurobiology, Center for Neural Circuits and Behavior, and Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.
Rüdiger KleinDepartment of Molecules - Signaling - Development, Max Planck Institute for Biological Intelligence, 82152 Martinsried, Germany.
Irina DudanovaDepartment of Molecules - Signaling - Development, Max Planck Institute for Biological Intelligence, 82152 Martinsried, Germany.
Takaki KomiyamaDepartment of Neurobiology, Center for Neural Circuits and Behavior, and Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0001-9609-4600

Funding

Cortical Control of Motor LearningR01NS091010 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIYAMA, TAKAKI · 2015 to 2024
$3.7M
Deconstructing Functional Circuits of Motor Cortex During Motor Learning - Microscope Repair Administrative SupplementR01NS125298 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Takaki Komiyama · 2022 to 2026
$2.8M
Cortical plasticity during reinforcement learning - Diversity SupplementR01MH128746 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Takaki Komiyama · 2022 to 2026
$2.3M
Context-dependent plasticity of adult-born neuronsR01DC018545 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KOMIYAMA, TAKAKI · 2020 to 2024
$2.2M
NIDCD NIH HHS R01 DC018545NIMH NIH HHS R01 MH128746NINDS NIH HHS R01 NS091010NINDS NIH HHS R01 NS125298
6 · The paper itself

Abstract

Huntington's disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptoms are poorly understood. These effects include cortical dysfunctions, yet the role of specific cortical neuronal subtypes in HD symptoms remain largely unexplored. Here, we used longitudinal

Identifiers

PMID39974900
PMCPMC11839025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.