Evidence map›Paper›PMID 39974888›Full record

ArticlebioRxiv : the preprint server for biology2025

A method for efficient, rapid, and minimally invasive implantation of individual non-functional motes with penetrating subcellular-diameter carbon fiber electrodes into rat cortex.

Joseph G Letner, Jordan L W Lam, Miranda G Copenhaver, Michael Barrow, Paras R Patel, Julianna M Richie, Jungho Lee, Hun-Seok Kim, Dawen Cai, James D Weiland and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Joseph G LetnerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-6584-6523
Jordan L W LamDepartment of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-3955-9031
Miranda G CopenhaverDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0009-0005-9294-9989
Michael BarrowDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-4038-3451
Paras R PatelDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-6146-718X
Julianna M RichieDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-8920-6560
Jungho LeeDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-4162-3389
Hun-Seok KimDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-6658-5502
Dawen CaiDepartment of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-4471-2061
James D WeilandDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-3453-9074
Jamie PhillipsDepartment of Electrical and Computer Engineering, University of Delaware, Newark, DE, 19716, USA.ORCID 0000-0003-2642-3717
David BlaauwDepartment of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-6744-7075
Cynthia A ChestekDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-9671-7051

Funding

Optimization and distribution of high density cellular scale carbon and silicon arraysUF1NS107659 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHESTEK, CYNTHIA ANNE · 2018 to 2018
$3.4M
Optical neural motes to enable high density recording through intact dura in a nonhuman primateRF1NS128667 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BLAAUW, DAVID, CHESTEK, CYNTHIA ANNE · 2022 to 2022
$2.6M
A multimodal platform to bridge the experimental gap between behavioral, neuronal, and molecular studiesRF1MH120005 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAI, DAWEN, CUI, MENG · 2019 to 2019
$2.3M
A novel approach to analyzing functional connectomics and combinatorial control in a tractable small-brain closed-loop systemR01NS118606 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BYRNE, JOHN H, CHESTEK, CYNTHIA ANNE · 2023 to 2024
$1.7M
NIMH NIH HHS RF1 MH120005NINDS NIH HHS R01 NS118606NINDS NIH HHS RF1 NS128667NINDS NIH HHS UF1 NS107659
6 · The paper itself

Abstract

Objective: Distributed arrays of wireless neural interfacing chips with 1-2 channels each, known as "neural dust", could enhance brain machine interfaces (BMIs) by removing the wired connection through the scalp and increasing biocompatibility with their submillimeter size. Although several approaches for neural dust have emerged, a procedure for implanting them in batches that builds upon the safety and performance of currently used electrodes remains to be demonstrated. Approach: Here, we demonstrate the feasibility of implanting batches of wireless motes that rest on the cortical surface with carbon fiber electrodes of subcellular diameter (6.8-8.4 μm) that penetrate to a target brain depth of 1 mm without insertion aids. To simulate their implantation, we assembled more than 230 mechanically equivalent motes and affixed them to insertion tools with polyethylene glycol (PEG), a quickly dissolvable and biocompatible material. Then, we implanted mote grids of multiple configurations into rat cortex Main Results: When placing motes onto the insertion device, we found that they aggregated in molten PEG such that the array pitch was only 5% wider than the dimensions of the mote bases themselves (240 × 240 μm). Overall, we found that motes with this arrangement could be inserted into rat cortex with a high success rate, as 171/186 (92%) motes in 4×4 (N=4) and 5×5 (N=5) square grid configurations were successfully inserted using the insertion device alone. After implantation, measurements of how much motes tilted (22±9°, X̄±S) and had been displaced relative to their original positions were smaller than those measured for devices implanted inside the brain in the literature. Significance: Collectively, these data establish the viability of safely implementing motes with ultrasmall electrodes and epicortically-situated chips for use in future BMIs.

Indexed as

electrode fabricationimplantationintracortical electrodesneural dustNeural probes

Identifiers

PMID39974888
PMCPMC11838573

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.