ArticleTranslational andrology and urology2025
Insomnia in relation to 10 urological and reproductive conditions: a two-sample Mendelian randomization study.
Article in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Neurobiology of Anxiety and Depression in CP/CPPS: A Narrative Review of Underlying Mechanisms.Neurology international · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The causal association of insomnia with multiple urological and reproductive conditions still lacks clarity. Our aim was to assess this relationship by examining impact of insomnia on 10 urological and reproductive conditions using Mendelian randomization (MR) designs. Methods: Summary statistics for insomnia and 10 urological and reproductive conditions were acquired from the UK Biobank, 23andMe, FinnGen, and genetic consortia. Inverse variance weighted approach was utilized as the main MR analysis. Sensitivity analyses were performed employing MR-PRESSO (Pleiotropy Residual Sum and Outlier), maximum likelihood, MR-Egger, and weighted median methods to examine the robustness of the estimates. Results: Genetically determined insomnia showed an elevated risk of cystitis [odds ratio (OR) =1.81; 95% confidence interval (CI): 1.47-2.24; P<0.001], and prostatitis (OR =3.53; 95% CI: 1.73-7.18; P<0.001) after Bonferroni correction. Suggestive evidence of an association was found between insomnia and a heightened risk of prostate cancer (OR =1.30; 95% CI: 1.00-1.67; P=0.046), alongside a decreased risk of bladder cancer (OR =0.48; 95% CI: 0.26-0.90; P=0.02). No causal effects were observed for kidney cancer, kidney and ureter calculus, neurogenic bladder, benign prostatic hyperplasia (BPH), male infertility, or female infertility. Conclusions: Findings support insomnia as a potential causal risk factor for cystitis and prostatitis. This highlights insomnia as an important target for reducing the risk of these diseases.
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