ArticleJournal of conservative dentistry and endodontics2025
A comparative evaluation of the decalcifying effects of ethylenediaminetetraacetic acid and N-acetyl cysteine on root canal dentin using energy-dispersive X-ray spectroscopy.
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Dentin tubule penetration of a calcium silicate-based sealer after removal of calcium hydroxide or N-acetylcysteine medicaments: an in vitro study.BMC oral health · 2026Article
- Article
- Evaluation of the Effectiveness of Different Caries Removal Methods in Primary Teeth With Micro-Computed Tomography and Scanning Electron Microscopy-Energy Dispersive Spectroscopy of X-Ray.Microscopy research and technique · 2025Article
- Evaluating the interaction of local anesthetic agents with sequential and continuous chelation in root dentin - AnJournal of conservative dentistry and endodontics · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Background: Chelating agents used to remove the inorganic part of the smear layer from prepared canals can alter dentin mineral composition, potentially affecting the adhesion of resin-based root canal cement and sealers. Aim: This study aimed to compare the decalcifying effects of 17% ethylenediaminetetraacetic acid (EDTA), 20% N-acetyl cysteine (NAC), and deionized water (control) on root canal dentin using energy-dispersive X-ray spectroscopy (EDXS). Materials and Methods: Sixty-nine extracted human mandibular premolars were randomly divided into three groups, yielding 138 root halves treated with either 17% EDTA, 20% NAC, or a control solution (n = 46). The mineral content was assessed using EDXS, and statistical analysis was conducted with the Kruskal-Wallis test, using an alpha level of 5%. Results: Twenty percent NAC and control groups retained more calcium, magnesium, and phosphorus than 17% EDTA, suggesting better mineral preservation, while 17% EDTA resulted in the lowest mineral content across all elements analyzed. Conclusion: Twenty percent NAC exhibited milder decalcifying effects compared to EDTA while preserving mineral content. Twenty percent NAC could be a biocompatible alternative to EDTA for smear layer removal in endodontic treatments.
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