ArticleJournal of conservative dentistry and endodontics2025
Article in Journal of conservative dentistry and endodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Cytocompatibility of calcium hydroxide medicament combined with cationic peptide - AnJournal of conservative dentistry and endodontics · 2026Article
- Biocompatible 3D hierarchical flower-like iron-doped silver nanostructures as a platform for in vitro and in vivo drug delivery.Scientific reports · 2026Article
- Evaluation of antimicrobial and antibiofilm efficacy of different antimicrobial peptides on multispecies biofilm of endodontic pathogens.Journal of conservative dentistry and endodontics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: The aim of this study was to assess the cytotoxicity of endodontic irrigants 2% chlorhexidine (CHX) and ethylenediaminetetraacetic acid (EDTA) combined with cationic peptide DJK-5 on L929 mouse subcutaneous fibroblast cells. Subjects and Methods: L929 cells were cultured and treated with 2% CHX, 2% CHX + DJK-5, 8.5% EDTA, 8.5% EDTA + DJK-5, and DJK-5 alone (DJK-5 peptide concentration-10 μg/mL) for 24 and 48 h. The cytotoxicity of the endodontic irrigants was determined using methyl thiazolyl tetrazolium assay and Live/Dead assay using acridine orange and ethidium bromide dual fluorescence staining. Statistical Analysis Used: The Shapiro-Wilk test was used to verify the normality of the data within each group at two different time points. Parametric tests were used for the comparison. Paired sample t-test was used for the comparison of the cytotoxicity of irrigants over time. One-way ANOVA was employed for the comparison of the cytotoxicity of irrigants. Tukey's test was used for pairwise comparison between groups. SPSS software version 27 was used for the data analyses. Results: CHX exhibited slight cytotoxicity at 24 h and higher cytotoxicity at 48 h (P < 0.05). EDTA showed better cell viability than CHX at both time points. In combination groups, the EDTA + DJK-5 group showed lower cytotoxicity at both time points (P > 0.05). The combination of CHX with DJK-5 reduced the cytotoxicity of CHX (P < 0.05). Conclusions: The cytotoxicity of endodontic irrigants was found to be time dependent. CHX was found to be highly cytotoxic at 2% concentration. DJK-5 was found to have the least cytotoxicity, and it significantly reduced the cytotoxicity of CHX and EDTA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.