ArticleThe journal of allergy and clinical immunology. Global2025
Alleviating effect of intranasal zinc on symptoms of allergic rhinitis.
Article in The journal of allergy and clinical immunology. Global, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Emerging Inverse Association Between Low Exposure to Vanadium and Kidney Function Impairment: a Cross-Sectional Analysis of Japanese Residents.Biological trace element research · 2026Article
- Article
- Glomerular Injury Induced by Daily Exposure to the Low-Frequency Component of Environmental Noise via Endothelin Signaling in Mice.Environmental science & technology · 2026Article
- The Role of Zinc in Pediatric Asthma and Allergic Rhinitis: Mechanisms and Clinical Implications.Nutrients · 2025Review
- Seasonal Proteomic Variations and Biomarkers in Seasonal Allergic Rhinitis: Insights from Olink Inflammation Profiling.Journal of inflammation research · 2025Article
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Authors and funding
15 authors.
Funding
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Abstract
Background: There is no information about the clinical implications and kinetics of zinc (Zn) in the nasal cavity, a center of allergic inflammation, and serum in subjects with allergic rhinitis (AR). Objective: Effects of intranasal Zn on symptoms before and after allergen provocation were investigated in humans and mice with or without AR. Methods: The first clinical follow-up study for Zn levels in nasal epithelial lining fluid (ELF) and serum was conducted in 57 control subjects and 44 patients with Japanese cedar pollinosis (JCP), a representative seasonal AR, from preseason to season. The clinical implications and kinetics of Zn levels in ELF and serum were further investigated in model mice with JCP. Results: This clinical study showed that the Zn level in nasal ELF from patients with JCP was increased after pollen exposure and became significantly higher than that in nasal ELF from controls in the JCP season. Conversely, the serum Zn level in patients was decreased after pollen exposure and became significantly lower than that in the controls in the JCP season. To further investigate the clinical implication of Zn level, model mice that mimicked the kinetics of intranasal and serum Zn levels as well as the symptoms in patients with JCP were established. The mouse interventional study showed that the symptoms of mice with provocative JCP were significantly improved by treatment with the putative human-equivalent dose of Zn. The relative number of mucin-secreting goblet cells, a sign of provocative allergic rhinitis, in the mice was decreased by intranasal treatment with Zn. Conclusion: The study's behavioral and pathologic results indicate that an increased level of intranasal Zn can alleviate symptoms of AR.
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