Evidence map›Paper›PMID 39974182›Full record

ReviewChem & bio engineering2024

Protein Corona of Nanoparticles: Isolation and Analysis.

Yinuo Sun, Yaxin Zhou, Mubashar Rehman, Yi-Feng Wang, Shutao Guo

Abstract readReview
In one paragraph

Review in Chem & bio engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yinuo SunKey Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China.
Yaxin ZhouKey Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China.
Mubashar RehmanSchool of Biomedical Engineering and Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Yi-Feng WangSchool of Biomedical Engineering and Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou 510260, China.
Shutao GuoKey Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China.ORCID https://orcid.org/0000-0002-0916-7451

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoparticles entering biological systems or fluids inevitably adsorb biomolecules, such as protein, on their surfaces, forming a protein corona. Ensuing, the protein corona endows nanoparticles with a new biological identity and impacts the interaction between the nanoparticles and biological systems. Hence, the development of reliable techniques for protein corona isolation and analysis is key for understanding the biological behaviors of nanoparticles. First, this review systematically outlines the approach for isolating the protein corona, including centrifugation, magnetic separation, size exclusion chromatography, flow-field-flow fractionation, and other emerging methods. Next, we review the qualitative and quantitative characterization methods of the protein corona. Finally, we underscore the necessary steps to advance the efficiency and fidelity of protein corona isolation and characterization on nanoparticle surfaces. We anticipate that these insights into protein corona isolation and characterization methodologies will profoundly influence the development of technologies aimed at elucidating bionano interactions and the role of protein corona in various biomedical applications.

Identifiers

PMID39974182
PMCPMC11792916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.