ArticlemedRxiv : the preprint server for health sciences2025
SEVERITY OF LUNG OBSTRUCTION AND OLDER AGE, BUT NOT PHYSICAL ACTIVITY, PREDICT LOCOMOTOR MUSCLE OXIDATIVE IMPAIRMENT IN COPD.
Alessandra Adami, Fenghai Duan, Robert A Calmelat, Zeyu Chen, Richard Casaburi, Harry B Rossiter
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Alessandra AdamiDepartment of Kinesiology, College of Health Sciences, University of Rhode Island, Kingston, RI, USA.ORCID 0000-0002-1917-9296 Fenghai DuanDepartment of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, RI, USA.ORCID 0000-0002-5084-0070 Robert A CalmelatInstitute of Respiratory Medicine and Exercise Physiology, Division of Pulmonary and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Zeyu ChenDepartment of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, RI, USA.
Richard CasaburiInstitute of Respiratory Medicine and Exercise Physiology, Division of Pulmonary and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0002-8851-8589 Harry B RossiterInstitute of Respiratory Medicine and Exercise Physiology, Division of Pulmonary and Critical Care Physiology and Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0002-7884-0726 Funding
ACTIV Integration of Host-targeting Therapies for COVID-19 Administrative Coordinating CenterOT2HL156812 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI NOLEN, TRACY L, THOMAS, SONIA M · 2020 to 2024
$1270.7MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MGENETIC EPIDEMIOLOGY OF COPD (COPD GENE) TASK A: STUDY VISIT 4, COLLECTION OF COPDGENE STUDY DATA ANDBIOSPECIMENS AND OVERSIGHT OF THE COPDGENE STUDY75N92023D00011 · NHLBI · NATIONAL JEWISH HEALTH · PI NEWMAN, LEE S · 2023 to 2025
$29.6MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7MMechanism Underlying the Transduction of Epimutations from the Soma to the Male GermlineP50HD098593 · NICHD · UNIVERSITY OF NEVADA RENO · PI ZHOU, TONG · 2019 to 2024
$7.2MA Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis PatientsR01DK122767 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RHEE, CONNIE MEEYOUNG · 2019 to 2023
$3.3MNovel cardiopulmonary exercise testing variables to differentiate neuromuscular deconditioning from diseaseR01HL166850 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Harry B Rossiter · 2023 to 2026
$3.1MCOPD Cachexia: Deciphering the Impact of Antioxidants, Iron and Mitochondrial Function Using 'Omics ApproachesR01HL153460 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MCDONALD DONNELLY, MERRY-LYNN NOELLE · 2021 to 2024
$2.7MDeterminants of 5 Year Progression of Muscle Dysfunction and Inactivity in COPDGene Participants Diversity SupplementR01HL151452 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ADAMI, ALESSANDRA, ROSSITER, HARRY B · 2020 to 2023
$1.6MNHLBI NIH HHS 75N92023D00011NHLBI NIH HHS OT2 HL156812NHLBI NIH HHS R01 HL151452NHLBI NIH HHS R01 HL153460NHLBI NIH HHS R01 HL166850NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NICHD NIH HHS P50 HD098593NIDDK NIH HHS R01 DK122767
6 · The paper itselfAbstract
Background: Low muscle oxidative capacity is an extrapulmonary manifestation of chronic obstructive pulmonary disease (COPD) with unclear etiology. We sought to determine clinical and behavioral features associated with muscle oxidative capacity in smokers with and without COPD and never smoker individuals. Methods: 243 adults enrolled in the Results: 241(99%) participants were allocated to analysis. FEV Conclusions: Locomotor muscle oxidative capacity was positively associated with FEV
Indexed as
Computed tomographyNear-infrared spectroscopyPhysical activityPRISmSmokersTriaxial accelerometry
Identifiers
PMID39974145
PMCPMC11838953
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