Evidence map›Paper›PMID 39974111›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Distress is positively associated with induced secondary hyperalgesia in people with suppressed HIV.

Luyanduthando Mqadi, Gillian J Bedwell, Ncumisa Msolo, Gwendoline Arendse, Maia Lesosky, Peter R Kamerman, Mark R Hutchinson, Andrew Schrepf, Robert R Edwards, John A Joska and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Luyanduthando MqadiAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-0542-2221
Gillian J BedwellAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4522-5679
Ncumisa MsoloAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0009-0000-1339-8060
Gwendoline ArendseAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0009-0008-5668-193X
Maia LesoskyNational Heart and Lung Institute, Imperial College London, London, United Kingdom.ORCID 0000-0002-2026-958X
Peter R KamermanDepartment of Physiology, School of Biomedical Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID 0000-0002-3103-5295
Mark R HutchinsonSchool of Biomedicine, University of Adelaide, South Australia, Australia.ORCID 0000-0003-2154-5950
Andrew SchrepfChronic Pain and Fatigue Research Center, Department of Anesthesiology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Robert R EdwardsDepartment of Anesthesiology, Perioperative, and Pain Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-4873-0443
John A JoskaHIV Mental Health Research Unit, Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4260-1181
Romy ParkerAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4823-2487
Victoria J MaddenAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-5357-4062

Funding

Psychosocial distress, inflammatory reactivity and central sensitization in the pathway to HIV-related pain: characterizing the associations and developing a pragmatic, coping-focused intervention.K43TW011442 · FIC · UNIVERSITY OF CAPE TOWN · PI MADDEN, VICTORIA JOY · 2019 to 2023
$674k
Mentorship in Precision Pain Medicine via EPPIC-NETK24NS126570 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R · 2021 to 2021
$319k
FIC NIH HHS K43 TW011442NINDS NIH HHS K24 NS126570
6 · The paper itself

Abstract

Pain and symptoms of depression and anxiety (here, 'psychological distress') are frequently reported by people with HIV. Although pain is widely acknowledged to contribute to distress, distress may also contribute to pain and its persistence. Facilitation of nociceptive signalling is one pathway by which distress could exacerbate pain. The current study investigated the relationships between symptoms of depression and anxiety, secondary hyperalgesia (SH), and persistent pain in people with HIV, reporting pain (n=19) or no pain (n=26). We hypothesised that self-reported distress would be positively associated with the surface area (primary measure) and magnitude (secondary measure) of induced SH, and that participants reporting persistent pain would display greater induced SH than those reporting no pain. We found that distress was positively associated with the surface area (p=0.02) and the magnitude (p=0.01) of induced SH. However, participants with persistent pain showed no difference in the surface area of SH compared to pain-free participants (p=0.87), and those with pain displayed a marginally lower magnitude of SH (p=0.05). These findings position SH as a potentially useful mechanistic outcome for interventions that aim to address pain by reducing symptoms of depression and anxiety. Perspective: Symptoms of depression and anxiety were positively associated with induced secondary hyperalgesia in people with suppressed HIV.

Indexed as

distressHIVpain-freepersistent painsecondary hyperalgesia

Identifiers

PMID39974111
PMCPMC11838949

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.