Evidence map›Paper›PMID 39974102›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Mitochondrial and Stress-Related Psychobiological Regulation of FGF21 in Humans.

Mangesh Kurade, Natalia Bobba-Alves, Catherine Kelly, Alexander Behnke, Quinn Conklin, Robert-Paul Juster, Michio Hirano, Caroline Trumpff, Martin Picard

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Mangesh KuradeDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-9664-6655
Natalia Bobba-AlvesDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-2783-6663
Catherine KellyDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0009-0007-8332-8528
Alexander BehnkeDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-4128-9627
Quinn ConklinDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-6121-2934
Robert-Paul JusterDepartment of Psychiatry and Addiction, University of Montreal, Montreal, Quebec, Canada.ORCID 0000-0003-4133-4042
Michio HiranoH. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA.
Caroline TrumpffDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-7070-5546
Martin PicardDivision of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-2835-0478

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Mitochondrial regulation of stress reactivity in humansR01MH122706 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2020 to 2024
$3.8M
Mitochondrial Energetics, Circuits and Cognitive Decline in the Aging Human BrainRF1AG076821 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2022 to 2022
$2.4M
Psychobiological regulation and molecular characterization of cell-free mitochondrial DNA in humansR01MH137190 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Martin Picard, Caroline Trumpff · 2024 to 2026
$2.4M
Mitochondrial Regulation of Stress Reactivity in HumansR21MH113011 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PICARD, MARTIN · 2017 to 2018
$440k
NCATS NIH HHS UL1 TR001873NCI NIH HHS P30 CA013696NIA NIH HHS RF1 AG076821NIMH NIH HHS R01 MH122706NIMH NIH HHS R01 MH137190NIMH NIH HHS R21 MH113011
6 · The paper itself

Abstract

FGF21 is a metabolic hormone induced by fasting, metabolic stress, and mitochondrial oxidative phosphorylation (OxPhos) defects that cause mitochondrial diseases (MitoD). Here we report that acute psychosocial stress alone (without physical exertion) decreases serum FGF21 by an average of 20% (

Indexed as

energy metabolismmitochondriamitochondrial disorderspsychobiologystress response

Identifiers

PMID39974102
PMCPMC11838639

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.