ArticlemedRxiv : the preprint server for health sciences2025
Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits.
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Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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65 authors.
Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.ORCID 0000-0003-0394-777X
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Alex P MillerDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Alexander S HatoumDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Joseph D DeakDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Jared V BalbonaDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
David Aa BarangerDepartment of Psychological and Brain Sciences, Washington University in St Louis, Saint Louis, MO, USA.
Marco GalimbertiDepartment of Human Genetics, Yale University School of Medicine, New Haven, CT, USA.
Kittipong SanichwankulSuanprung Psychiatric Hospital, Chiang Mai, Thailand.
Thorgeir ThorgeirssondeCODE Genetics/Amgen, Sturlugata 8, IS-101, Reykjavik, Iceland.
Sarah Mc ColbertDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Keyrun AdhikariDepartment of Human Genetics, Yale University School of Medicine, New Haven, CT, USA.
Anna DochertyDepartment of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, USA.
Louisa DegenhardtNational Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia.
Tobias EdwardsDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Louis FoxDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Alexandros GiannelisDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Paul JeffriesDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Tellervo KorhonenInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Claire MorrisonDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Yaira Z NunezDepartment of Human Genetics, Yale University School of Medicine, New Haven, CT, USA.
Teemu PalviainenInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Mei-Hsin SuVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Pamela N Romero VillelaDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Leah WetherillDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Emily A WilloughbyDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Stephanie ZellersInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Laura BierutDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Jadwiga BuchwaldInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
William CopelandDepartment of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, USA.
Robin CorleyInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
Naomi P FriedmanDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Nathan A GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Ian R GizerDepartment of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Ian B HickieBrain and Mind Institute, University of Sydney, New South Wales, Sydney, Australia.
Jaakko A KaprioInstitute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland.
Matthew C KellerDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
James L LeeDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Penelope A LindPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Pamela A MaddenDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Hermine Hm MaesVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Matt McGueDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Sarah E MedlandPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Elliot C NelsonDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
John V PearsonPsychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Bernice PorjeszHenri Begleiter Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Health Science University, Brooklyn, NY, USA.
Michael StallingsDepartment of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.
Scott VriezeDepartment of Psychology, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Kirk C WilhelmsenDepartment of Neurology and Genetics and the Bowles Center of Alcohol Studies, University of North Carolina, Chapel Hill, NC, USA.
Raymond K WaltersAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Renato PolimantiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Robert T MalisonDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Hang ZhouDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Kari StefanssondeCODE Genetics/Amgen, Sturlugata 8, IS-101, Reykjavik, Iceland.
Marc N PotenzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Apiwat MutiranguraDepartment of Anatomy, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Vorasuk ShotelersukCenter of Excellence for Medical Genomics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Rasmon KalayasiriDepartment of Psychiatry, Epidemiology of Psychiatric Disorders and Mental Health Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Howard J EdenbergDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Joel GelernterDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine in St Louis, Saint Louis, MO, USA.
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MJH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2MTwin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5MThe Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3MDeep sequencing studies for cannabis and stimulant dependenceR01DA030976 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EHLERS, CINDY L, GELERNTER, JOEL · 2010 to 2014
$16.5MSex-specific analysis of opioid dependence GWAS and beyondR01DA012690 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2000 to 2017
$14.0MPILOT--GENETIC EPIDEMIOLOGY OF ALCOHOL AND TOBACCO CONSUMPTION IN CHINESE SAMPLEP50AA011998 · NIAAA · WASHINGTON UNIVERSITY · PI HEATH, ANDREW C. · 1999 to 2008
$12.6MGENETICS OF COCAINE DEPENDENCER01DA012849 · NIDA · YALE UNIVERSITY · PI GELERNTER, JOEL · 1999 to 2010
$11.5MTHE GENETICS OF VULNERABILITY TO NICOTINE ADDICTIONSR01DA012854 · NIDA · WASHINGTON UNIVERSITY · PI MADDEN, PAMELA ANN · 2000 to 2013
$10.4MThe Effects of Cannabis Legalization and Persistent Use: A Longitudinal Study of Two Twin CohortsR01DA042755 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Jarrod Martin Ellingson, SOO H RHEE · 2017 to 2026
$9.9MTWIN STUDY OF FEMALE ALCOHOLISMS AND OTHER DISORDERSR01AA009367 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 1992 to 2013
$9.0MBIOMEDICAL RESEARCH TRAINING IN DRUG ABUSET32DA007261 · NIDA · WASHINGTON UNIVERSITY · PI ARPANA AGRAWAL, Jose A Moron-Concepcion · 1991 to 2026
$8.8MNCI NIH HHS P01 CA089392NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS N01 HG065403NHGRI NIH HHS U01 HG004422NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NIAAA NIH HHS K01 AA031724NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K05 AA000145NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA009367NIAAA NIH HHS R01 AA011330NIAAA NIH HHS R01 AA011886NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA014041NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R01 AA017444NIAAA NIH HHS R01 AA017535NIAAA NIH HHS R37 AA007728NIAAA NIH HHS R37 AA009367NIAAA NIH HHS R37 AA012502NIAAA NIH HHS U10 AA008401NIA NIH HHS R01 AG077742NIDA NIH HHS DP1 DA054394NIDA NIH HHS K01 DA051759NIDA NIH HHS K01 DA058807NIDA NIH HHS K08 DA019951NIDA NIH HHS K24 DA032555NIDA NIH HHS P60 DA011015NIDA NIH HHS R00 DA023549NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA011301NIDA NIH HHS R01 DA012690NIDA NIH HHS R01 DA012845NIDA NIH HHS R01 DA012849NIDA NIH HHS R01 DA012854NIDA NIH HHS R01 DA013240NIDA NIH HHS R01 DA013423NIDA NIH HHS R01 DA017305NIDA NIH HHS R01 DA018432NIDA NIH HHS R01 DA019963NIDA NIH HHS R01 DA021905NIDA NIH HHS R01 DA021913NIDA NIH HHS R01 DA024413NIDA NIH HHS R01 DA030976NIDA NIH HHS R01 DA035804NIDA NIH HHS R01 DA042755NIDA NIH HHS R01 DA044283NIDA NIH HHS R01 DA054087NIDA NIH HHS R01 DA054869NIDA NIH HHS R37 DA005147NIDA NIH HHS R56 DA012854NIDA NIH HHS RC2 DA028909NIDA NIH HHS T32 DA007261NIDA NIH HHS U01 DA024413NIMH NIH HHS K01 MH093731NIMH NIH HHS K23 MH080230NIMH NIH HHS R01 MH048085NIMH NIH HHS R01 MH063671NIMH NIH HHS R01 MH063970NIMH NIH HHS R01 MH066140NIMH NIH HHS R01 MH077874NIMH NIH HHS R01 MH100141NIMH NIH HHS R01 MH123489NIMH NIH HHS R01 MH123619NIMH NIH HHS R01 MH134284Wellcome Trust
Abstract
Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. We conducted a genome-wide association study of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry, 10,231 of African ancestry, 3,746 of East Asian ancestry) and compared the results to other nicotine-related phenotypes. We replicated the well-known association at the
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