Evidence map›Paper›PMID 39974060›Full record

ArticlemedRxiv : the preprint server for health sciences2025

A novel lncRNA FAM151B-DT regulates autophagy and degradation of aggregation prone proteins.

Arun Renganathan, Miguel A Minaya, Matthew Broder, Isabel Alfradique-Dunham, Michelle Moritz, Reshma Bhagat, Jacob Marsh, Anthony Verbeck, Grant Galasso, Emma Starr and 3 more

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Arun RenganathanDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.
Miguel A MinayaDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.
Matthew BroderDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.
Isabel Alfradique-DunhamDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.
Michelle MoritzDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.
Reshma BhagatDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.
Jacob MarshDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.
Anthony VerbeckDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.
Grant GalassoDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.
Emma StarrDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.
David A AgardDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.
Carlos CruchagaDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.
Celeste M KarchDepartment of Psychiatry, Washington University in St Louis, St Louis, MO.ORCID 0000-0002-6854-5547

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI David G DeNardo · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal ProteasesU54NS123985 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KARCH, CELESTE MARIE · 2021 to 2025
$9.0M
Glacios™ Cryo Transmission Electron Microscope with 200 kV XFEG opticsS10OD026881 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHENG, YIFAN · 2019 to 2019
$1.8M
Targeting Tau Proteoforms in Frontotemporal DementiaRF1NS110890 · NINDS · WASHINGTON UNIVERSITY · PI KARCH, CELESTE MARIE · 2021 to 2021
$1.8M
Targeting Tau Proteoforms in Frontotemporal DementiaR01NS110890 · NINDS · WASHINGTON UNIVERSITY · PI KARCH, CELESTE MARIE · 2024 to 2024
$575k
Targeting Tau Proteoforms in Frontotemporal DementiaR56NS110890 · NINDS · WASHINGTON UNIVERSITY · PI KARCH, CELESTE MARIE · 2019 to 2019
$558k
Molecular drivers of tauopathies in stem cell models from diverse human populationsK01AG083215 · NIA · WASHINGTON UNIVERSITY · PI Miguel Minaya · 2023 to 2026
$508k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIA NIH HHS K01 AG083215NIA NIH HHS P30 AG066444NIDDK NIH HHS P30 DK020579NIH HHS S10 OD026881NINDS NIH HHS R01 NS110890NINDS NIH HHS R56 NS110890NINDS NIH HHS RF1 NS110890NINDS NIH HHS U54 NS123985
6 · The paper itself

Abstract

Neurodegenerative diseases share common features of protein aggregation along with other pleiotropic traits, including shifts in transcriptional patterns, neuroinflammation, disruptions in synaptic signaling, mitochondrial dysfunction, oxidative stress, and impaired clearance mechanisms like autophagy. However, key regulators of these pleotropic traits have yet to be identified. Here, we discovered a novel long non-coding RNA (lncRNA),

Identifiers

PMID39974060
PMCPMC11838976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.