Automated Segmentation of Trunk Musculature with a Deep CNN Trained from Sparse Annotations in Radiation Therapy Patients with Metastatic Spine Disease.

Purpose: Given the high prevalence of vertebral fractures post-radiotherapy in patients with metastatic spine disease, accurate and rapid muscle segmentation could support efforts to quantify muscular changes due to disease or treatment and enable biomechanical modeling for assessments of vertebral loading to improve personalized evaluation of vertebral fracture risk. This study presents a deep-learning approach for segmenting the complete volume of the trunk muscles from clinical CT images trained using sparsely annotated data. Materials and Methods: we extracted 2,009 axial CT images at the midpoint of each vertebral level (T4 to L4) from clinical CT of 148 cancer patients. The key extensor and flexor muscles (up to 8 muscles per side) were manually contoured and labeled per image in the thoracic and lumbar regions. We first trained a 2D nnU-Net deep-learning model on these labels to segment key extensor and flexor muscles. Using these sparse annotations per spine, we trained the model to segment each muscle's entire 3D volume. Results: The proposed method achieved comparable performance to manual segmentations, as assessed by expert radiologists, with a mean Dice score above 0.769. Significantly, the model drastically reduced segmentation time, from 4.3-6.5 hours for manual segmentation of 14 single axial CT images to approximately 1 minute for segmenting the complete thoracic-abdominal 3D volume. Conclusion: The approach demonstrates high potential for automating 3D muscle segmentation, significantly reducing the manual intervention required for generating musculoskeletal models, and could be instrumental in enhancing clinical decision-making and patient care in radiation oncology.