Evidence map›Paper›PMID 39974014›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Accelerated Metabolomic Aging and Its Association with Social Determinants of Health in Multiple Sclerosis.

Fatemeh Siavoshi, Rezvan Noroozi, Gina Chang, Vinicius A Schoeps, Matthew D Smith, Farren B S Briggs, Jennifer S Graves, Emmanuelle Waubant, Ellen M Mowry, Peter A Calabresi and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Fatemeh SiavoshiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-8562-9523
Rezvan NorooziDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2294-171X
Gina ChangDepartment of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Vinicius A SchoepsDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8875-0567
Matthew D SmithDepartment of Epidemiology, Johns Hopkins University School of Public Health, Baltimore, MD, USA.ORCID 0000-0001-6614-569X
Farren B S BriggsDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.ORCID 0000-0003-0903-1359
Jennifer S GravesDepartment of Neurosciences, University of California, San Diego, San Diego, CA, USA.
Emmanuelle WaubantDepartment of Neurology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5188-0157
Ellen M MowryDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peter A CalabresiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Pavan BhargavaDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7947-9418
Kathryn C FitzgeraldDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-3137-0322

Funding

Metabolic predictors of disease outcomes in multiple sclerosisR01NS133005 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Kathryn C. Fitzgerald · 2024 to 2026
$1.9M
Characterizing the serum metabolome in multiple sclerosisR01NS121928 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BRIGGS, FARREN B. S. · 2021 to 2023
$1.4M
Metabolic correlates of disease activity and disability progression in pediatric MSR01NS117541 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAUBANT, EMMANUELLE LAURENCE · 2021 to 2023
$1.1M
Understanding the role of aromatic amino acid derived metabolic toxins in neuroinflammationR21NS123141 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BHARGAVA, PAVAN · 2022 to 2023
$450k
NINDS NIH HHS R01 NS117541NINDS NIH HHS R01 NS121928NINDS NIH HHS R01 NS133005NINDS NIH HHS R21 NS123141
6 · The paper itself

Abstract

Objectives: Biological age may better capture differences in disease course among people with multiple sclerosis (PwMS) of identical chronological age. We investigated biological age acceleration through metabolomic age (mAge) in PwMS and its association with social determinants of health (SDoH) measured by area deprivation index (ADI). Methods: mAge was calculated for three cohorts: 323 PwMS and 66 healthy controls (HCs); 101 HCs and 71 DMT-naïve PwMS; and 64 HCs and 67 pediatric-onset MS/clinically isolated syndrome patients, using an aging clock derived from 11,977 healthy adults. mAge acceleration, the difference between mAge and chronological age, was compared between groups using generalized linear and mixed-effects models, and its association with ADI was assessed via linear regression. Results: Cross-sectionally, PwMS had higher age acceleration than HCs: 9.77 years in adult PwMS (95% CI:6.57-12.97, p=5.3e-09), 4.90 years in adult DMT-naïve PwMS (95% CI:0.85-9.01, p=0.02), and 6.98 years (95% CI:1.58-12.39, p=0.01) in pediatric-onset PwMS. Longitudinally, PwMS aged 1.19 mAge years per chronological year (95% CI:0.18, 2.20; p=0.02), faster than HCs. In PwMS, a 10-percentile increase in ADI was associated with a 0.63-year (95% CI:0.10-1.18; p=0.02) increase in age acceleration. Discussion: We demonstrated accelerated mAge in adult and pediatric-onset PwMS and its association with social disadvantage.

Identifiers

PMID39974014
PMCPMC11838630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.