Evidence map›Paper›PMID 39973987›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Plasma proteins are integral to gene-regulatory networks acting within and across blood cells, the arterial wall and major metabolic organs.

Sean Bankier, Husain Talukdar, Mariyam Khan, Giuseppe Mocci, Katyayani Sukhavasi, Ke Hao, Angela Ma, Arno Ruusalepp, Eric E Schadt, Jason C Kovacic and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sean BankierComputational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.ORCID 0000-0001-5069-3165
Husain TalukdarDepartment of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.
Mariyam KhanComputational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.
Giuseppe MocciDepartment of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.
Katyayani SukhavasiDepartment of Cardiac Surgery and The Heart Clinic, Tartu University Hospital and Department of Cardiology, Institute of Clinical Medicine, Tartu University, Tartu, Estonia.
Ke HaoDepartment of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA.
Angela MaDepartment of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA.
Arno RuusaleppDepartment of Cardiac Surgery and The Heart Clinic, Tartu University Hospital and Department of Cardiology, Institute of Clinical Medicine, Tartu University, Tartu, Estonia.
Eric E SchadtDepartment of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029-6574, USA.
Jason C KovacicCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York 10029, NY, USA.
Tom MichoelComputational Biology Unit, Department of Informatics, University of Bergen, Bergen, Norway.ORCID 0000-0003-4749-4725
Johan Lm BjörkegrenDepartment of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.

Funding

Multimodal genetic regulatory architecture of coronary artery diseaseR01HL148239 · NHLBI · UNIVERSITY OF VIRGINIA · PI Clint L Miller · 2019 to 2026
$4.2M
Integrative genomic and functional genomic studies to connect variant to function for CAD GWAS lociR01HL168174 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wei Li, EDOARDO MARCORA · 2023 to 2026
$3.1M
Understanding the Molecular Mechanisms of Fibromuscular DysplasiaR01HL148167 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KADIAN-DODOV, DANIELLA, KOVACIC, JASON CIRIL · 2020 to 2023
$2.8M
Systems Genetics of Vascular Smooth Muscle PhenotypesR01HL166428 · NHLBI · UNIVERSITY OF VIRGINIA · PI Mete Civelek · 2023 to 2026
$2.4M
Functional genomics investigation of pleiotropic vascular disease lociR01HL164577 · NHLBI · UNIVERSITY OF VIRGINIA · PI MILLER, CLINT L · 2022 to 2025
$2.3M
NHLBI NIH HHS R01 HL148167NHLBI NIH HHS R01 HL148239NHLBI NIH HHS R01 HL164577NHLBI NIH HHS R01 HL166428NHLBI NIH HHS R01 HL168174
6 · The paper itself

Abstract

The plasma proteome is the future for diagnostic markers for common diseases, like cardiometabolic disorders (CMDs) and coronary artery disease (CAD). The reliability of these markers requires identifying their source-organ(s). We profiled 974 plasma proteins in 532 CAD-patients of the STARNET study with arterial wall, major metabolic organ, and blood transcriptomic data. 144 plasma cis-pQTLs colocalized with tissue eQTLs including eight CMD/CAD GWAS genes. 262 plasma proteins correlated with their corresponding tissue "seed" genes whereof 101 in the liver. 851 plasma proteins were strongly associated with the activity of gene-regulatory networks (GRNs), particularly cross-tissue GRNs. The Adipose-Liver Plasma LeptIN-regulating GRN78 with the top key driver

Indexed as

cardiometabolic disorderscoronary artery diseasegene expressiongene regulatory networksgenome wide association studyplasma protein levelsprotein quantitative trait loci

Identifiers

PMID39973987
PMCPMC11839005

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.