Evidence map›Paper›PMID 39973982›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Provoked cytokine response is not associated with distress or induced secondary hyperalgesia in people with suppressed HIV.

Victoria J Madden, Luyanduthando Mqadi, Gwen Arendse, Gillian J Bedwell, Ncumisa Msolo, Maia Lesosky, Mark R Hutchinson, Jonathan G Peter, Andrew Schrepf, Romy Parker and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Victoria J MaddenAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-5357-4062
Luyanduthando MqadiAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-0542-2221
Gwen ArendseAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0009-0008-5668-193X
Gillian J BedwellAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4522-5679
Ncumisa MsoloAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Maia LesoskyNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-2026-958X
Mark R HutchinsonSchool of Biomedicine, University of Adelaide, South Australia, Australia.ORCID 0000-0003-2154-5950
Jonathan G PeterDivision of Allergy and Clinical Immunology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Rondebosch, South Africa.ORCID 0000-0002-2658-0723
Andrew SchrepfChronic Pain and Fatigue Research Center, Department of Anesthesiology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-4291-0320
Romy ParkerAfrican Pain Research Initiative, Department of Anaesthesia and Perioperative Medicine, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4823-2487
Robert R EdwardsDepartment of Anesthesiology, Perioperative, and Pain Medicine, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-4873-0443
John A JoskaHIV Mental Health Research Unit, Department of Psychiatry and Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-4260-1181

Funding

Neuroimmune Interface in Urological Chronic Pelvic Pain SyndromeR01DK123164 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARTE, STEVEN EDWARD, SCHREPF, ANDREW · 2020 to 2024
$2.6M
The impact of hormonal modulation on systemic inflammation and central sensitizationR01HD108253 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sawsan As-Sanie, Andrew Schrepf · 2023 to 2026
$2.6M
Immune-mediated adverse drug reactions to HIV and TB treatments in South Africa: predict, prevent and improve long-term outcomes (IMARI SA study)R01AI152183 · NIAID · UNIVERSITY OF CAPE TOWN · PI MEINTJES, GRAEME AYTON, PHILLIPS, ELIZABETH · 2020 to 2025
$1.6M
Psychosocial distress, inflammatory reactivity and central sensitization in the pathway to HIV-related pain: characterizing the associations and developing a pragmatic, coping-focused intervention.K43TW011442 · FIC · UNIVERSITY OF CAPE TOWN · PI MADDEN, VICTORIA JOY · 2019 to 2023
$674k
IMmune-mediated Adverse drug Reactions In African HIV endemic setting (IMARI-SA study)K43TW011178 · FIC · UNIVERSITY OF CAPE TOWN LUNG INSTITUTE · PI PETER, JONATHAN · 2018 to 2022
$648k
Mentorship in Precision Pain Medicine via EPPIC-NETK24NS126570 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R · 2021 to 2021
$319k
FIC NIH HHS K43 TW011178FIC NIH HHS K43 TW011442NIAID NIH HHS R01 AI152183NICHD NIH HHS R01 HD108253NIDDK NIH HHS R01 DK123164NINDS NIH HHS K24 NS126570
6 · The paper itself

Abstract

Psychological distress predicts the onset and worsening of persistent pain, but the mechanisms that underpin this influence are poorly understood. Pro-inflammatory signalling is a plausible mechanistic link, given its known connections to distress, pain, and neural upregulation. Sustained distress may prime the inflammatory system to respond more strongly to a phasic noxious challenge, supporting neuroimmune upregulation of central nociceptive signalling and persistent pain. This cross-sectional study tested the hypotheses that

Indexed as

cytokinesHIVhyperalgesiahypersensitivityinflammationneuroimmunomodulationpainpsychological distresssecondary hyperalgesia

Identifiers

PMID39973982
PMCPMC11838944

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.