ArticleJournal of clinical laboratory analysis2025
Reference Interval Establishment for Neutrophil-To-Lymphocyte Ratio, Platelet-To-Lymphocyte Ratio, and Systemic Immune-Inflammation Index in Athletes: Analysis of Sex and Sport Type Impact.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Inflammatory biomarkers and 30-day thoracic outcomes after surgical versus non-surgical management of spontaneous pneumothorax: a retrospective cohort study.Frontiers in medicine · 2026Article
- Comprehensive Evaluation of Non-Standard Inflammatory and Metabolic Indices in Obesity: A Single-Center Retrospective Study.Healthcare (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveTo establish sex- and sport-specific reference intervals (RIs) for the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) in athletes.
methodsA retrospective study analyzed 13,647 entries from elite athletes (2018-2024), categorized by sex and six sport types. RIs were developed using a training set (9555 entries) and validated with a separate set (4092 entries). The RIs were defined using the 2.5th and 97.5th percentiles of the distribution.
resultsFemales had higher RIs compared to males: NLR (females: 1.53 [0.74, 3.25]; males: 1.36 [0.70, 2.89]), PLR (females: 124 [69, 223]; males: 111 [65, 188]), and SII (females: 347 [146, 804]; males: 298 [139, 684]) (p < 0.001). Sport type influenced RIs, with significant differences noted across categories (p < 0.001). Validation showed an outlier rate below 10% across all groups, confirming robustness.
conclusionThese sex- and sport-specific RIs enhance the precision of health assessments, supporting early detection of overtraining and inflammation in athletes. Future studies should expand to diverse populations and consider factors like age and training cycles.
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