Evidence map›Paper›PMID 39973524›Full record

ArticleJournal of neonatal-perinatal medicine2025

Concordance of maternal and cord blood SARS-COV-2 immunoglobulin seropositivity after COVID-19 infection or vaccination in pregnancy.

Gladys Rojas, Aarti Jain, Fayez Bany-Mohammed, Philip Felgner, Muhammad Aslam, Cherry C Uy

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Article in Journal of neonatal-perinatal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gladys RojasDepartment of Pediatrics, Division of Neonatology, University of California Irvine, Orange, CA, USA.
Aarti JainDepartment of Physiology and Biophysics, University of California Irvine, Orange, CA, USA.
Fayez Bany-MohammedDepartment of Pediatrics, Division of Neonatology, University of California Irvine, Orange, CA, USA.
Philip FelgnerDepartment of Physiology and Biophysics, University of California Irvine, Orange, CA, USA.
Muhammad AslamDepartment of Pediatrics, Division of Neonatology, University of California Irvine, Orange, CA, USA.
Cherry C UyDepartment of Pediatrics, Division of Neonatology, University of California Irvine, Orange, CA, USA.ORCID 0000-0002-9103-8412

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveTo assess maternal antibody response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection during pregnancy and subsequent transplacental antibody transfer in cord blood.Study DesignThis is a prospective cohort study of Coronavirus Disease 2019 (COVID-19) polymerase chain reaction (PCR) positive pregnant women and their newborns. SARS-CoV-2 PCR (+) women were enrolled, with SARS-CoV-2 PCR (-) as control. Maternal blood was obtained at enrollment and cord blood collected at delivery. Baseline maternal and infant characteristics and neonatal outcomes were collected. Samples were analyzed using coronavirus antigen microarray containing immunologically significant antigens from SARS-CoV-2 (including nucleocapsid protein [NP], spike protein [S], S1, S2, receptor-binding domain [RBD]) which can detect SARS-CoV-2 immunoglobulin G (IgG) and immunoglobulin M (IgM).ResultsThirty-seven maternal-cord blood paired samples were analyzed for SARS-CoV-2 IgG or IgM antibodies; 15 out of 20 samples from SARS-CoV-2 PCR (+) and 14 out of 17 from SARS-CoV-2 PCR (-) mothers were IgG positive. 14 out of the 17 SARS-CoV-2 PCR (-) mothers received COVID-19 vaccine during pregnancy. Difference between IgG seropositivity of naturally infected versus vaccinated mothers were significant, 75% versus 100% (

Indexed as

Antibodies, ViralCOVID-19COVID-19 VaccinesFetal BloodImmunity, Maternally-AcquiredImmunoglobulin GPregnancy Complications, InfectiousSARS-CoV-2AdultFemaleHumansImmunoglobulin MInfant, NewbornPregnancyProspective StudiesVaccinationAntibodies, ViralCOVID-19 VaccinesImmunoglobulin GImmunoglobulin Mcord bloodCOVID-19IgGIgMimmunoglobulinSARS-CoV-2SARS-CoV-2 vaccinevertical transmission

Identifiers

PMID39973524
PMCPMC12231836

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.