Evidence map›Paper›PMID 39973509›Full record

ArticleJournal of Parkinson's disease2025

Cortical α4β2-nicotinic acetylcholine receptors and cognitive decline in Parkinson's disease.

Kelly A Mills, Hiroto Kuwabara, Yong Du, Gabriela Gomez, Chelsie S Motley, Yana Skorobogatova, Ergi Spiro, Jennifer M Coughlin, Wojciech Lesniak, Jason Brandt and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Increased Binding of [Synapse (New York, N.Y.) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kelly A MillsDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-4302-1501
Hiroto KuwabaraRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yong DuRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Gabriela GomezJohns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-1761-0070
Chelsie S MotleyDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0003-9468-1627
Yana SkorobogatovaRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ergi SpiroRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0009-0006-0849-0106
Jennifer M CoughlinJohns Hopkins Brain Health Program, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wojciech LesniakDepartment of Radiology, University of Texas Southwestern School of Medicine, Dallas, TX, USA.
Jason BrandtDivision of Medical Psychology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vidya KamathDivision of Medical Psychology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-7711-3597
Martin G PomperDepartment of Radiology, University of Texas Southwestern School of Medicine, Dallas, TX, USA.
Gwenn S SmithRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
Longitudinal Molecular Imaging of Neuropathology and Serotonin in Mild Cognitive ImpairmentR01AG059390 · NIA · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2018 to 2022
$4.8M
Molecular Imaging of the Nicotinic Cholinergic Receptor in Parkinson's disease (PD): Implication of for understanding the neurobiology of cognitive impairmentK23NS101096 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MILLS, KELLY ALEXANDER · 2017 to 2021
$1000k
NCATS NIH HHS KL2 TR001077NCATS NIH HHS UL1 TR001079NIA NIH HHS R01 AG059390NINDS NIH HHS K23 NS101096
6 · The paper itself

Abstract

BackgroundAutopsy and

Indexed as

Cerebral CortexCognitive DysfunctionHippocampusParkinson DiseaseReceptors, NicotinicAgedFemaleHumansMaleMiddle AgedPositron-Emission Tomographynicotinic receptor alpha4beta2Receptors, Nicotiniccognitive dysfunctionnicotinic cholinergic receptorParkinson's diseasePET imaging

Identifiers

PMID39973509
PMCPMC12413266

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.