Evidence map›Paper›PMID 39973498›Full record

ArticleJournal of Parkinson's disease2025

The effect of polygenic risk score on PD risk and phenotype in

Orly Goldstein, Shachar Shani, Mali Gana-Weisz, Nadav Elkoshi, Fergal Casey, Yu H Sun, Khyati Chandratre, Jesse M Cedarbaum, Cornelis Blauwendraat, Anat Bar-Shira and 6 more

Abstract read
In one paragraph

Article in Journal of Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Commentary: Pesticides andJournal of Parkinson's disease · 2026
    Article
  3. Genetic Modifiers of Parkinson's Disease: A Case-Control Study.Annals of clinical and translational neurology · 2025
    Observational
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Orly GoldsteinLaboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.ORCID 0000-0001-7781-2734
Shachar ShaniFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0003-2188-4514
Mali Gana-WeiszLaboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Nadav ElkoshiLaboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.ORCID 0000-0003-4546-2922
Fergal CaseyFormerly Biogen Inc, Cambridge, MA, USA.
Yu H SunResearch Data Sciences, Translational Biology, Biogen Inc., Cambridge, MA, USA.ORCID 0000-0003-0333-2898
Khyati ChandratreResearch Data Sciences, Translational Biology, Biogen Inc., Cambridge, MA, USA.
Jesse M CedarbaumFormerly Biogen Inc, Cambridge, MA, USA.
Cornelis BlauwendraatCenter for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Anat Bar-ShiraLaboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Avner ThalerFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Tanya GurevichFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Anat MirelmanFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0002-1520-2292
Nir GiladiFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0003-1482-8522
Avi Orr-UrtregerLaboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.ORCID 0000-0001-9305-6203
Roy N AlcalayLaboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.ORCID 0000-0002-5717-4875

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundWhile

Indexed as

Genetic Predisposition to DiseaseGlucosylceramidaseLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Multifactorial InheritanceParkinson DiseaseAdultAgedFemaleGenetic Risk ScoreHeterozygoteHumansJewsMaleMiddle AgedPhenotypeGBA protein, humanGlucosylceramidaseLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanalpha-synucleinGBA1LRRK2Parkinson's diseasepolygenic risk score

Identifiers

PMID39973498
PMCPMC13347430

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.