Evidence map›Paper›PMID 39973467›Full record

ArticleJournal of neuromuscular diseases2024

Peripheral defects precede neuromuscular pathology in the

Aoife Reilly, Ariane Beauvais, Majd Al-Aarg, Rebecca Yaworski, Emma R Sutton, Simon Thebault, Rashmi Kothary

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuromuscular diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aoife ReillyRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Ariane BeauvaisRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Majd Al-AargRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0009-0006-4108-3852
Rebecca YaworskiRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Emma R SuttonRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Simon ThebaultPerelman School of Medicine, University of Pennsylvania, Philadelphia, USA.ORCID 0000-0003-0395-3395
Rashmi KotharyRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.ORCID 0000-0002-9239-7310

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpinal Muscular Atrophy (SMA) is an inherited neurodegenerative disease caused by the loss or mutation of the survival motor neuron 1

objectiveHere, we characterized several neuronal and non-neuronal defects in the

methodsWe collected tissues from mutant

results

conclusionsThis work provides an important framework for guiding future research with this mouse model and demonstrates that the liver may be an early target in the development of SMA.

Indexed as

Motor NeuronsMuscular Atrophy, SpinalNeuromuscular JunctionAnimalsDisease Models, AnimalIslets of LangerhansMiceMice, KnockoutNeurofilament ProteinsSpinal CordSurvival of Motor Neuron 2 Proteinneurofilament protein LNeurofilament ProteinsSurvival of Motor Neuron 2 Proteinanimal modelsbiomarkersblood glucoselivermetabolismmotor neuronsmusclesneurofilament proteinneuromuscular junctionpancreas

Identifiers

PMID39973467
PMCPMC13108007

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.