Evidence map›Paper›PMID 39973292›Full record

ArticleJournal of chemical information and modeling2025

Estimating Absolute Protein-Protein Binding Free Energies by a Super Learner Model.

Elton J F Chaves, João Sartori, Whendel M Santos, Carlos H B Cruz, Emmanuel N Mhrous, Manassés F Nascimento Filho, Matheus V F Ferraz, Roberto D Lins

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. SARS-CoV-2 NSP8-Derived Peptide Effectively Suppresses the Activity of Helicase NSP13.Computational and structural biotechnology journal · 2026
    Article
  4. Journal of chemical information and modeling · 2025
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Elton J F ChavesAggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife 50670-465, Brazil.ORCID 0000-0001-8573-2216
João SartoriLaboratory for Applied Genomics and Bio-Innovations, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil.
Whendel M SantosDepartment of Fundamental Chemistry, Federal University of Pernambuco, Recife 50670-901, Brazil.
Carlos H B CruzInstitute of Structural and Molecular Biology, University College London, London WC1E 6BT, U.K.
Emmanuel N MhrousDepartment of Computer Science, Princeton University, Princeton, New Jersey 08544, United States.
Manassés F Nascimento FilhoInstitute of Structural and Molecular Biology, University College London, London WC1E 6BT, U.K.
Matheus V F FerrazNEC OncoImmunity AS, Oslo 0349, Norway.ORCID 0000-0002-6958-3115
Roberto D LinsAggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife 50670-465, Brazil.ORCID 0000-0002-3983-8025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein-protein binding is central to most biochemical processes of all living beings. Its importance underlies mechanisms ranging from cell interactions to metabolic control, but also to

Indexed as

Machine LearningProteinsProtein BindingThermodynamicsProteins

Identifiers

PMID39973292
PMCPMC11898044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.