Evidence map›Paper›PMID 39973210›Full record

ArticleEvolution & development2026

Genetic Mapping of Orofacial Traits Reveals a Single Genomic Region Associated With Differences in Multiple Parameters of Jaw Size Between Astyanax mexicanus Surface and Cavefish.

Amanda K Powers, Alleigh Amaismeier, Kathryn Thiel, William Anyonge, Suzanne E McGaugh, Tyler E Boggs, Clifford J Tabin, Joshua B Gross

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evolution & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Automated Profiling of Social Behaviors to Assess the Genetic Basis of Evolution of Aggressive Behaviors in Astyanax mexicanus.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amanda K PowersDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, Massachusetts, USA.
Alleigh AmaismeierDepartment of Biology, Xavier University, Cincinnati, Ohio, USA.
Kathryn ThielDepartment of Biology, Xavier University, Cincinnati, Ohio, USA.
William AnyongeDepartment of Biology, Xavier University, Cincinnati, Ohio, USA.
Suzanne E McGaughDepartment of Ecology, Evolution and Behavior, University of Minnesota, Saint Paul, Minnesota, USA.
Tyler E BoggsDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
Clifford J TabinDepartment of Genetics, Blavatnik Institute at Harvard Medical School, Boston, Massachusetts, USA.
Joshua B GrossDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.

Funding

Investigating modes of cartilage cell size regulation and fate during endochondral ossificationF32AR076187 · NIAMS · HARVARD MEDICAL SCHOOL · PI POWERS, AMANDA K · 2019 to 2021
$198k
NIAMS NIH HHS F32 AR076187This study was supported by National Institutes of Health.
6 · The paper itself

Abstract

The regulation of bone size is a poorly understood and complex developmental process. Evolutionary models can enable insight through interrogation of the developmental and molecular underpinnings of natural variation in bone size and shape. Here, we examine the Mexican tetra (Astyanax mexicanus), a species of teleost fish comprising of an extant river-dwelling surface fish and obligate cave-dwelling fish. These divergent morphs have evolved for thousands of years in drastically different habitats, which have led to diverse phenotypic differences. Among many craniofacial aberrations, cavefish harbor a wider gape, an underbite, and larger jaws compared to surface-dwelling morphs. Morphotypes are inter-fertile, allowing quantitative genetic analyses in F

Indexed as

CharacidaeJawQuantitative Trait LociAnimalsBiological EvolutionCavesChromosome MappingMalePhenotypecavefishfeeding behaviorjawsquantitative trait loci

Identifiers

PMID39973210
PMCPMC12353297

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.