Evidence map›Paper›PMID 39973137›Full record

ArticleZoological research2025

Post-translational cleavage generates truncated IgY forms in the snake

Ming Zhang, Long Hua, Tang-Yuan Xie, Tao Wang, Li-Juan Du, Di Yu, Han-Wei Cao, Jin-Cheng Zhong, Geng-Sheng Cao, Xiang Ding and 3 more

Abstract read
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In one paragraph

Article in Zoological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Ming ZhangKey Laboratory of Qinghai-Xizang Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Southwest Minzu University, Chengdu, Sichuan 610041, China.
Long HuaHenan Province Livestock Gene Editing Biotechnology Breeding Engineering Center, School of Life Sciences, Henan University, Kaifeng, Henan 475000, China.
Tang-Yuan XieHenan Province Livestock Gene Editing Biotechnology Breeding Engineering Center, School of Life Sciences, Henan University, Kaifeng, Henan 475000, China.
Tao WangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China.
Li-Juan DuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China.
Di YuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China.
Han-Wei CaoState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China.
Jin-Cheng ZhongKey Laboratory of Qinghai-Xizang Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Southwest Minzu University, Chengdu, Sichuan 610041, China.
Geng-Sheng CaoHenan Province Livestock Gene Editing Biotechnology Breeding Engineering Center, School of Life Sciences, Henan University, Kaifeng, Henan 475000, China.
Xiang DingLaboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Hai-Tang HanState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China.
Yao-Feng ZhaoState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, Frontiers Science Center for Molecular Design Breeding, China Agricultural University, Beijing 100193, China. E-mail: yaofengzhao@cau.edu.cn.
Tian HuangHenan Province Livestock Gene Editing Biotechnology Breeding Engineering Center, School of Life Sciences, Henan University, Kaifeng, Henan 475000, China. E-mail: huangtian@henu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While variable regions of immunoglobulins are extensively diversified by V(D)J recombination and somatic hypermutation in vertebrates, the constant regions of immunoglobulin heavy chains also utilize certain mechanisms to produce diversity, including class switch recombination (CSR), subclass differentiation, and alternative expression of the same gene. Many species of birds, reptiles, and amphibians express a truncated isoform of immunoglobulin Y (IgY), termed IgY(ΔFc), which lacks the υCH3 and υCH4 domains. In Anseriformes, IgY(ΔFc) arises from alternative transcriptional termination sites within the same υ gene, whereas in some turtles, intact IgY and IgY(ΔFc) are encoded by distinct genes. Different from the previously reported IgY(ΔFc) variants, this study identified a truncated IgY in the snake

Indexed as

ImmunoglobulinsProtein Processing, Post-TranslationalSnakesAmino Acid SequenceAnimalsGene Expression RegulationHumansIgYImmunoglobulinsAsparaginyl endopeptidasePost-translational cleavageTruncated IgY

Identifiers

PMID39973137
PMCPMC12000142

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