Evidence map›Paper›PMID 39973069›Full record

ArticleJournal of medical primatology2025

Determination of Minimum Alveolar Concentrations of Isoflurane and Effective Plasma Concentration of Propofol in Common Marmosets (Callithrix jacchus).

Kanako Muta, Makoto Koizumi, Takako Miyabe-Nishiwaki, Yusuke Sotomaru, Asako Nobukiyo, Hiroki Ohta, Hirotaka James Okano, Masatoshi Kamata, Dai Nagakubo, Ryohei Nishimura

Abstract read
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In one paragraph

Article in Journal of medical primatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kanako MutaLaboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-6424-1538
Makoto KoizumiLaboratory Animal Facilities, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Takako Miyabe-NishiwakiCenter for Human Evolution Modeling Research, Center for the Evolutionary Origins of Human Behavior, Kyoto University, Kyoto, Aichi, Japan.
Yusuke SotomaruNatural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan.
Asako NobukiyoNatural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan.
Hiroki OhtaDivision of Regenerative Medicine, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Hirotaka James OkanoDivision of Regenerative Medicine, Research Center for Medical Sciences, The Jikei University School of Medicine, Tokyo, Japan.
Masatoshi KamataVeterinary Medical Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Dai NagakuboVeterinary Medical Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Ryohei NishimuraLaboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Funding

2017th Agricultural Emergence Fund (Support for young researchers) by the University of Tokyo
6 · The paper itself

Abstract

backgroundCommon marmosets (Callithrix jacchus) have been widely used as laboratory animals; However, limited sedation and anesthetic protocols have yet to be established. In this study, the minimum alveolar concentration of an inhalant (isoflurane) and effective predicted plasma concentration of an injectable anesthetic (propofol) were measured for optimization of sedation and anesthetic protocols in marmosets.

methodsThe minimum alveolar concentrations (MACs) for several stimulations (nociceptive stimulation, endotracheal intubation, and non-painful direct stimulation), MAC-noci, MAC-extb, and MAC-awake, respectively, were measured for isoflurane with the up-and-down method from four healthy marmosets. Predicted plasma concentrations 50 (Cp50s), which are equivalent to MACs of isoflurane, Cp50-noci, Cp50-extb, and Cp50-awake, respectively, were measured for propofol.

resultsMAC-noci and MAC-extb of isoflurane in marmosets were 1.91% and 1.38%, respectively. MAC-awake was not determined owing to technical difficulties. Cp50-noci, Cp50-extb, and Cp50-awake were 9.45, 7.21, and 3.54 μg/mL, respectively.

conclusionsThe obtained results refined existing isoflurane and propofol for sedation and anesthesia in marmosets.

Indexed as

Anesthetics, InhalationAnesthetics, IntravenousCallithrixHypnotics and SedativesIsofluranePropofolPulmonary AlveoliAnimalsFemaleMaleAnesthetics, InhalationAnesthetics, IntravenousHypnotics and SedativesIsofluranePropofolanesthesiacommon marmoseteffective plasma concentrationisofluraneminimum alveolar concentrationspropofol

Identifiers

PMID39973069
PMCPMC11840290

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.