Evidence map›Paper›PMID 39973018›Full record

ReviewBJOG : an international journal of obstetrics and gynaecology2026

Standardised Methods for Developing Conceptual Frameworks for Placental Disorders of Pregnancy: Pre-Eclampsia and Stillbirth.

Terteel Elawad, Mai-Lei Woo Kinshella, Ellie Stokes, Kelly Pickerill, Elisa Dalle Piagge, Marianne Vidler, Ella Stanley, Marie-Laure Volvert, Jeffrey N Bone, Helen Elwell and 8 more

Abstract readReview
In one paragraph

Review in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Determinants of Pre-Eclampsia: Advancing a Conceptual Framework.BJOG : an international journal of obstetrics and gynaecology · 2026
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Terteel ElawadRoyal Free London NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-4432-1485
Mai-Lei Woo KinshellaDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0001-5846-3014
Ellie StokesRoyal United Hospitals Bath NHS Foundation Trust, Bath, UK.
Kelly PickerillDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Elisa Dalle PiaggeNHS Lothian Foundation School, Edinburgh, UK.
Marianne VidlerDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0002-7633-8812
Ella StanleySchool of Medicine, University of Leeds, Leeds, UK.
Marie-Laure VolvertBMA Library, British Medical Association, London, UK.ORCID https://orcid.org/0000-0002-0527-4145
Jeffrey N BoneDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0001-7704-1677
Helen ElwellBMA Library, British Medical Association, London, UK.
Hiten D MistryDepartment of Women and Children's Health, King's College London, London, UK.ORCID https://orcid.org/0000-0003-2564-7348
Violet MateljanPreeclampsia Foundation Canada, Fonthill, Ontario, Canada.
Eleni TsigasPreeclampsia Foundation, Melbourne, Florida, USA.
Veronique FilippiCentre for Maternal Adolescent Reproductive and Child Health (MARCH), London School of Hygiene and Tropical Medicine, London, UK.
Peter von DadelszenDepartment of Women and Children's Health, King's College London, London, UK.ORCID https://orcid.org/0000-0003-4136-3070
Hannah BlencoweCentre for Maternal Adolescent Reproductive and Child Health (MARCH), London School of Hygiene and Tropical Medicine, London, UK.
Laura A MageeDepartment of Women and Children's Health, King's College London, London, UK.ORCID https://orcid.org/0000-0002-1355-610X
PRECISE Network

Funding

Medical Research Council MR/P027938/1NIHR-Wellcome PartnershipUK Research and InnovationWellcome Trust 217123
6 · The paper itself

Abstract

backgroundRisk factors for the placental disorders of pregnancy (pre-eclampsia, fetal growth restriction, preterm birth, and stillbirth) are complex, frequently involving the interplay between clinical factors and wider social and environmental determinants of health. Biomarkers modulate the maternal and fetal responses to biological processes that underlie the development of placental disorders.

objectivesTo develop a standardised methodology to assess the importance of, and inter-relationships between, candidate risk factors for the various placental disorders. SEARCH STRATEGY: Systematic searches were conducted using Medline, Embase, Health Technology Assessments, Database of Abstracts of Reviews of Effects, Cochrane Library databases, Google Scholar, and reference lists of retrieved papers. SELECTION CRITERIA: We deployed a hierarchy of reviews, systematic reviews, and cohort studies with at least 1000 participants (100 for biomarker studies), published in the prior decade. DATA COLLECTION AND ANALYSIS: We assessed the strengths of association and quality of evidence linking risk factors with individual placental outcomes.

conclusionsWe have developed a standardised approach to assess the importance and inter-relatedness of putative risk factors for the placental disorders of pregnancy.

Indexed as

Placenta DiseasesPre-EclampsiaStillbirthBiomarkersFemaleFetal Growth RetardationHumansPregnancyPremature BirthRisk FactorsBiomarkersconceptual frameworkfetal growth restrictionplacental disorderspre‐eclampsiapreterm birthstillbirth

Identifiers

PMID39973018
PMCPMC7618178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.