Evidence map›Paper›PMID 39972951›Full record

ArticleBrain and behavior2025

Serum Angiopoietin-Like Protein 4 as a Biomarker for Acute Ischemic Stroke Severity and Dynamic Changes.

Fang Guo, Chong Zheng, Tao Yang, Fang-Wei Hu, Yan-Gui Chen, Chia-Wei Liou, Bin Cai

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In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Fang GuoDepartment of Neurology and Institute of Neurology, First Affiliated Hospital, Institute of Neuroscience, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Chong ZhengDepartment of Neurology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.
Tao YangDepartment of Neurology and Institute of Neurology, First Affiliated Hospital, Institute of Neuroscience, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Fang-Wei HuDepartment of Neurology and Institute of Neurology, First Affiliated Hospital, Institute of Neuroscience, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
Yan-Gui ChenDepartment of Neurology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, China.
Chia-Wei LiouDepartment of Neurology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Bin CaiDepartment of Neurology and Institute of Neurology, First Affiliated Hospital, Institute of Neuroscience, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.ORCID https://orcid.org/0000-0003-2659-9376

Funding

Fujian Province Natural Science Foundation 2021J011443Joint Funds for the innovation of science and Technology, Fujian province 2018Y9084Joint Funds for the innovation of science and Technology, Fujian province 2023Y9039Natural Science Foundation of China 82071277Natural Science Foundation of China 82471299
6 · The paper itself

Abstract

backgroundAngiopoietin-like protein 4 (ANGPTL4) is critical for vascular integrity and reducing inflammation in ischemic and hypoxic brain injuries. However, limited studies have evaluated ANGPTL4's role in acute ischemic stroke (AIS) assessment, and its expression patterns across AIS phases remain unclear.

methodsThe severity of AIS at admission was assessed using the National Institutes of Health Stroke Scale (NIHSS). The association between serum ANGPTL4 level and the occurrence of AIS was examined using logistic regression analysis. The diagnostic accuracy of serum ANGPTL4 level for AIS severity was assessed using receiver operating characteristic curves.

resultsThis study included 389 AIS patients and 133 healthy individuals. There was a notable increase in the occurrence of AIS associated with rising serum ANGPTL4 levels (odds ratio [OR] 1.03, 95% confidence interval [CI]: 1.02-1.06; p < 0.001). A higher serum level of ANGPTL4 was also found to be associated with severe AIS, as indicated by an AUC of 0.848. Additionally, we observed significant dynamic changes in ANGPTL4 levels, with a marked decrease at 1 week or 2 weeks after admission compared with the acute phase (the day after admission; both p < 0.001).

conclusionsOur findings suggest a robust association between elevated serum ANGPTL4 levels and the presence and severity of AIS. Importantly, this study is distinguished by its novel focus on the temporal dynamics of ANGPTL4 levels, which underscores its potential as a biomarker for AIS monitoring and provides new insights into AIS pathophysiology.

Indexed as

Angiopoietin-Like Protein 4Ischemic StrokeAgedBiomarkersFemaleHumansMaleMiddle AgedSeverity of Illness IndexAngiopoietin-Like Protein 4ANGPTL4 protein, humanBiomarkersacute ischemic strokeangiopoietin‐like protein 4NIHSS

Identifiers

PMID39972951
PMCPMC11839744

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