ArticleHuman brain mapping2025
Transdiagnostic Connectome-Based Prediction of Response Inhibition.
Article in Human brain mapping, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Bridging molecules and connectome: network biomarkers guided by neurotransmitter architecture in major depressive disorder.Translational psychiatry · 2026Article
- Predicting apathy using connectome-based models derived from static and dynamic brain connectivity.Social cognitive and affective neuroscience · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
Response inhibition (RI) deficits are a core feature across diagnostic categories of mental disorders. However, it remains unclear whether the brain networks underlying different forms of RI deficits are disorder-shared or disorder-specific, and how they interact with aberrant brain connectivity across disorders. Connectome-based predictive modeling (CPM) provides a novel approach for exploring the brain networks associated with RI abnormalities across diagnostic categories of mental disorders. Publicly available resting-state functional magnetic resonance imaging data from individuals with schizophrenia (n = 47), bipolar disorder (n = 47), and attention-deficit/hyperactivity disorder (n = 40), as well as healthy controls (n = 121), were utilized to construct whole-brain network predictive models for different forms of RI (action cancellation and action restraint). The brain networks of different forms of RI were further compared with abnormal brain networks in the diagnostic groups. Action restraint and action cancellation exhibited both shared and distinct brain networks. There was a dissociation in the relationship between the brain networks underlying different forms of RI and the aberrant connectivity patterns observed across diagnostic categories. Our models successfully predicted action restraint performance across diagnostic categories, whereas the model failed to effectively predict action cancellation due to the influence of disease-related aberrant connectivity on the brain networks underlying action cancellation. Nevertheless, the action cancellation model demonstrated generalizability to novel, healthy participants (n = 220) from an independent dataset. Our study clarifies the complex relationship between deficits in RI and the neuropathology of mental disorders and provides a foundation for more accurate cognitive assessment and targeted interventions. Our findings highlight the importance of refining RI constructs and emphasize the value of applying connectome methods to reveal cross-diagnostic neural mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.